Common Cold pp 197-210 | Cite as

Transmission of colds

  • Diane E. Pappas
  • J. Owen Hendley
Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)


Rhinorrhea, nasal congestion, and sore throat herald the beginning of the cold season for both children and adults. Although the common cold is a self-limited infection, there are no effective treatments presently available and complications, missed time from work and school, and overall discomfort are not insignificant. Understanding how infections are transmitted may lead to interventions to reduce rates of infection. In order to establish a route of transmission, certain conditions must be met. The virus must be produced and shed at the site of infection. The virus must be deposited in the environment and be able to survive there. The virus must then be able to reach the portal of entry. Finally, interruption of the proposed route of transmission must reduce the incidence of infection under natural conditions. Applying this framework, there is clear evidence in both experimental and home settings that colds can be transmitted via self-inoculation. A small amount of evidence is available relating to large and small particle aerosol transmission. Because rhinovirus is responsible for half of all colds, it has been used as the model to understand how virus is transmitted from one person to another in experimental settings. Rhinovirus has been shown to infect via self-inoculation following hand-to-hand contact with contaminated hands or hand-to-surface contact with contaminated objects in the environment. Similarly, there is convincing evidence that the self-inoculation method of cold virus transmission occurs in the home environment, where colds arre most often transmitted. Aerosol transmission has been studied in the experimental setting and may provide another, albeit less common method for transmission of rhinovirus infection. As more is understood about the transmission of cold viruses, effective methods to interrupt transmission may be devised.


Respiratory Syncytial Virus Common Cold Nasolacrimal Duct Secondary Transmission Hand Sanitizer 


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  1. 1.
    Peltola V, Waris M, Osterback R et al. (2008) Rhinovirus transmission within families with children: Incidence of symptomatic and asymptomatic infections. J Infect Dis 197:382–389CrossRefPubMedGoogle Scholar
  2. 2.
    Hendley JO (1999) Clinical virology of rhinoviruses. Adv Virus Res 54:453–466CrossRefPubMedGoogle Scholar
  3. 3.
    Winther B, Gwaltney, JM, Mygind, N et al. (1986) Sites of rhinovirus recovery after point inoculation of the upper airway. JAMA 256:1763CrossRefPubMedGoogle Scholar
  4. 4.
    Arruda E, Boyle TR, Winther B et al. (1995) Localization of human rhinovirus replication in the upper respiratory tract by in situ hybridization. J Infect Dis 171:1329–1333PubMedGoogle Scholar
  5. 5.
    Bardin PG, Johnston SL, Sanderson G et al. (1994) Detection of rhinovirus infection of the nasal mucosa by oligonucleotide in situ hybridization. Am J Respir Cell Mol Biol 10:207–213PubMedGoogle Scholar
  6. 6.
    Papadopoulos, NG, Bates, PJ, Bardin, PG et al. (2000) Rhinoviruses infect the lower airways. J Infect Dis 181:1876–1884CrossRefGoogle Scholar
  7. 7.
    Gwaltney JM Jr, Hendley JO (1988) Mechanisms of transmission of rhinovirus infections. Epidemiol Rev 10:242–258Google Scholar
  8. 8.
    Winther B, McCue K, Ashe K et al. (2007) Environmental contam ination with rhinovirus and transfer to fingers of healthy individuals by daily life activity. J. Med Virol 79:1606–1610CrossRefPubMedGoogle Scholar
  9. 9.
    Hendley JO, Wenzel RP, Gwaltney JM Jr (1973) Transmission of rhinovirus colds by self-inoculation. N Engl J Med 288:1361–1364PubMedCrossRefGoogle Scholar
  10. 10.
    Reed SE (1975) An investigation of the possible transmission of rhinovirus colds through indirect contact. J Hyg (Camb) 75:249–258CrossRefGoogle Scholar
  11. 11.
    Gwaltney JM Jr, Moskalski PB, Hendley JO. (1980) Interruption of experimental rhinovirus transmission. J Infect Dis 142:811–815PubMedGoogle Scholar
  12. 12.
    D’Alessio DJ, Peterson JA, Dick CR, Dick EC. (1976) Transmission of experimental rhinovirus colds in volunteer married couples. J Infect Dis 133:28–36PubMedGoogle Scholar
  13. 13.
    Gwaltney JM Jr (1980) Epidemiology of the common cold. Ann NY Acad Sci 353:54–60CrossRefPubMedGoogle Scholar
  14. 14.
    Myatt TA, Johnston SL, Zuo Z et al. (2004) Detection of airborne rhinovirus and its relation to outdoor air supply in office environments. Am J Respir Crit Care Med 169:1187–1190CrossRefPubMedGoogle Scholar
  15. 15.
    Zitter JN, Mazonson PD, Miller DP et al. (2002) Aircraft cabin air recirculation and symptoms of the common cold. JAMA 288:483–486CrossRefPubMedGoogle Scholar
  16. 16.
    Gwaltney JM Jr, Hendley JO (1978) Rhinovirus transmission: One if by air, two if by hand. Am J Epidemiol 107:357–361PubMedGoogle Scholar
  17. 17.
    Huynh KN, Oliver BG, Stelzer S et al. (2008) A new method for sampling and detection of exhaled respiratory virus aerosols. Clin Infect Dis 46:93–95CrossRefPubMedGoogle Scholar
  18. 18.
    Hall CB, Douglas RG (1981) Modes of transmission of respiratory syncytial virus. J Pediatr 99:100–103CrossRefPubMedGoogle Scholar
  19. 19.
    Hendley JO (2000) The common cold. In: RL Cecil, JC Bennett, L Boldman (eds): Cecil Textbook of Medicine, 21st edn. WB Saunders, Philadlphia, 1790–1793Google Scholar
  20. 20.
    D’Alessio DJ, Meschievitz CK, Peterson JA et al. (1984) Short-duration exposure and the transmission of rhinoviral colds. J Infect Dis 150:189–194PubMedGoogle Scholar
  21. 21.
    Gwaltney JM Jr, Hendley JO (1982) Transmission of experimental rhinovirus infection by contaminated surfaces. Am J Epidemiol 116:828–832PubMedGoogle Scholar
  22. 22.
    Dick EC, Jennings LC, Mink KA et al. (1987) Aerosol transmission of rhinovirus colds. J Infect Dis 156:442–448PubMedGoogle Scholar
  23. 23.
    Gwaltney JM Jr, Moskalski PB, Hendley JO (1978) Hand-to-hand transmission of rhinovirus colds. Ann Intern Med 88:463–467PubMedGoogle Scholar
  24. 24.
    Hayden GF, Gwaltney JM Jr, Thacker DF, Hendley JO (1985) Rhinovirus inactivation by nasal tissues treated with virucide. Antiviral Res 5:103–109CrossRefPubMedGoogle Scholar
  25. 25.
    Hayden GF, Hendley JO, Gwaltney JM Jr (1985) The effect of placebo and virucidal paper handkerchiefs on viral contamination of the hand and transmission of experimental rhinoviral infection. J Infect Dis 152:403–407PubMedGoogle Scholar
  26. 26.
    Lee GM, Salomon JA, Friedman JF, Hibberd PL et al. (2004) Illness transmission in the home: a possible role for alcohol-based hand gels. Pediatrics 115: 852–860CrossRefGoogle Scholar
  27. 27.
    Sandora TJ, Shih, M, Goldmann DA (2008) Reducing absenteeism from gastrointestinal and respiratory illness in elementary school students: A randomized, controlled trial of an infection-control intervention. Pediatrics 121: e1555–e1562CrossRefPubMedGoogle Scholar
  28. 28.
    Sandora TJ, Taveras EM, Shih M et al. (2005) A randomized controlled trial of a multifaceted intervention including alcohol-based hand sanitizer and handhygiene education to reduce illness transmission in the home. Pediatrics 116: 587–594CrossRefPubMedGoogle Scholar
  29. 29.
    Farr BM, Hendley JO, Kaiser DL, Gwaltney JM (1988) Two randomized, controlled trials of virucidal nasal tissues in the prevention of natural upper respiratory infections. Am J Epidemiol 128:1162–1172PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Diane E. Pappas
    • 1
  • J. Owen Hendley
    • 1
  1. 1.University of Virginia Department of PediatriesCharlottesvilleUSA

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