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Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths

  • David E. Elliott
  • Joel V. Weinstock
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Variations in more than 40 genetic loci can alter the risk for developing inflammatory bowel disease (IBD). However, the epidemiology of ulcerative colitis and Crohn’s disease suggest that a recent environmental change accounts for most of the disease risk. In this chapter we will introduce IBD and outline its dramatic rise in prevalence over the last 70 years. We will consider the effective eradication of helminths during this time period and the effects of helminths on immunity. We will review the current evidence that helminths induce regulatory immune circuits that suppress aberrant inflammation and may be useful clinically to treat immune-mediated disease.

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Intestinal Epithelium Lymphatic Filariasis Helminth Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • David E. Elliott
    • 1
    • 2
  • Joel V. Weinstock
    • 3
  1. 1.Division of Gastroenterology and Hepatology, Department of Internal MedicineUniversity of Iowa, Roy J. and Lucille A. Carver College of MedicineIowa CityUSA
  2. 2.VAMCIowa CityUSA
  3. 3.Division of Gastroenterology and Hepatology, Department of Internal MedicineTufts Medical CenterBostonUSA

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