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Mechanism of erythropoietin receptor activation

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Book cover Erythropoietins, Erythropoietic Factors, and Erythropoiesis

Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

Erythropoietin receptor (EPOR) is a founding member of the cytokine receptor superfamily [1]. A type I transmembrane protein that binds the ligand erythropoietin (EPO) with high affinity (kDa approximately 400 pM) on the surface of erythroid progenitors, EPOR is devoid of catalytic activity. Given that the extracellular domain of EPOR only contains two cytokine receptor homology modules (D1 and D2), EPOR is considered a simple (or short) receptor, unlike other superfamily members, like the receptors for interleukin (IL)-6 type cytokines or for granulocyte colony-stimulating factor (G-CSF), which possess other extracellular sequences, such as immunoglobulin-like domains [2].

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research and de Duve Institute, Université catholique de Louvain, Brussels, B1200, Belgium

    Stefan N. Constantinescu

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  1. Stefan N. Constantinescu
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  1. Amgen Inc., One Amgen Center Drive, Mailstop 29-1-A, Thousand Oaks, CA, 91320, USA

    Steven G. Elliott

  2. MA Foote Associates, Westlake Village, CA, 91362, USA

    Mary Ann Foote

  3. Amgen Inc., One Amgen Center Drive, Mailstop 15-2-A, Thousand Oaks, CA, 91320, USA

    Graham Molineux

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Constantinescu, S.N. (2009). Mechanism of erythropoietin receptor activation. In: Elliott, S.G., Foote, M.A., Molineux, G. (eds) Erythropoietins, Erythropoietic Factors, and Erythropoiesis. Milestones in Drug Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8698-6_11

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