Lessons from the ArKO mouse

  • Evan R. Simpson
  • Margaret E. Jones
  • Colin D. Clyne
Part of the Milestones in Drug Therapy book series (MDT)


Oestrogen biosynthesis is catalyzed by a microsomal member of the cytochrome P450 superfamily, namely aromatase cytochrome P450 (P450 arom, the product of the CYP19 gene). The P450 gene superfamily is a very large one, containing over 3000 members in some 350 families, of which cytochrome P450 arom is the sole member of family 19 (see http://drnelson.utmem.edu/cytochromeP450.html). This haem protein is responsible for binding of the C19 androgenic steroid substrate and catalyzing the series of reactions leading to formation of the phenolic A ring characteristic of oestrogens.


CYP19 Gene Aromatase Activity Aromatase Expression Adipose Stromal Cell ArKO Mouse 
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Copyright information

© Birkhäuser Verlag/Switzerland 2008

Authors and Affiliations

  • Evan R. Simpson
    • 1
  • Margaret E. Jones
    • 1
  • Colin D. Clyne
    • 1
  1. 1.Prince Henry’s Institute of Medical Research, Department of Biochemistry and Molecular BiologyMonash UniversityMelbourneAustralia

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