Lessons from the ArKO mouse

  • Evan R. Simpson
  • Margaret E. Jones
  • Colin D. Clyne
Part of the Milestones in Drug Therapy book series (MDT)


Oestrogen biosynthesis is catalyzed by a microsomal member of the cytochrome P450 superfamily, namely aromatase cytochrome P450 (P450 arom, the product of the CYP19 gene). The P450 gene superfamily is a very large one, containing over 3000 members in some 350 families, of which cytochrome P450 arom is the sole member of family 19 (see This haem protein is responsible for binding of the C19 androgenic steroid substrate and catalyzing the series of reactions leading to formation of the phenolic A ring characteristic of oestrogens.


CYP19 Gene Aromatase Activity Aromatase Expression Adipose Stromal Cell ArKO Mouse 
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Copyright information

© Birkhäuser Verlag/Switzerland 2008

Authors and Affiliations

  • Evan R. Simpson
    • 1
  • Margaret E. Jones
    • 1
  • Colin D. Clyne
    • 1
  1. 1.Prince Henry’s Institute of Medical Research, Department of Biochemistry and Molecular BiologyMonash UniversityMelbourneAustralia

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