Clinical studies with anastrozole

  • Anthony Howell
  • Alan Wakeling
Part of the Milestones in Drug Therapy book series (MDT)


Oestrogens play a dominant role in controlling the growth of many breast cancers [1, 2]. The ovaries are the primary source of oestrogen in premenopausal women but ovarian oestrogen production diminishes with age. In postmenopausal women, oestrogens are synthesised by the aromatisation of androgen precursors in the skin, muscle, adipose and breast tissue, including malignant breast tumours [3]. Oestrogen action is inhibited by blocking the oestrogen receptor (ER) with antioestrogens such as tamoxifen, by ovarian ablation using surgery, radiotherapy or luteinising hormone-releasing hormone analogs such as goserelin, or, in postmenopausal women, by blocking oestrogen production by inhibiting aromatase activity [4].


Breast Cancer Postmenopausal Woman Aromatase Inhibitor Advanced Breast Cancer Early Breast Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag/Switzerland 2008

Authors and Affiliations

  • Anthony Howell
    • 1
  • Alan Wakeling
    • 2
  1. 1.CRUK Department of Medical OncologyChristie Hospital NHS TrustManchesterUK
  2. 2.Department of Cancer and Infection ResearchAstraZeneca PharmaceuticalsMacclesfieldUK

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