Dual role of IL-17 in allergic asthma

  • Bruno Schnyder
  • Silvia Schnyder-Candrian
Part of the Progress in Inflammation Research book series (PIR)


A proinflammatory role of IL-17 in autoimmune disorders has been favored, although there is evidence that IL-17 has a dual role as negative regulator. Here we review the concept of dual IL-17 functions in the light of recent strategies to use IL-17 neutralization as potential alternative to neutralizing TNF and IL-1 treatments in chronic inflammatory disorders. Expectedly, in allergic lung inflammation, neutralization of IL-17 inhibited neutrophil recruitment. However, this IL-17 antibody treatment concomitantly increased eosinophil recruitment by neutralizing IL-17’s dual role as negative regulator. IL-17 negatively regulated dendritic cell function and activation of T helper cell (Th)2 cytokine production. Furthermore, IL-17 inhibited Th2-characteristic chemokine and adhesion molecule expression. On a mechanistic level, IL-17 acted on IκB-β by preventing degradation and in turn leading to reduced NF-κB activation or IL-17 inhibited transcription factor IRF-1. Therefore, anti-IL-17 therapy, although presenting a promising lead in chronic inflammatory disorders, bears a potential risk of exacerbating allergic asthma.


Experimental Autoimmune Encephalomyelitis Treg Cell Allergic Asthma iNKT Cell Chronic Inflammatory Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Bruno Schnyder
    • 1
  • Silvia Schnyder-Candrian
    • 1
  1. 1.Molecular Immunology and Embryology (IEM)Université d’Orléans and CNRSOrléans Cedex 2France

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