IL-25, another promoter of allergy
Although there have been significant insights into the mechanism underlying the initiation of type 1 immune response, how type 2-mediated pathology especially allergic diseases is developed remains unclear. Cytokine environment is important in shaping and initiating Th2 responses. IL-25, also called IL-17E, belongs to the IL-17 family but, unlike other IL-17 cytokine members, possesses a unique function in regulating type 2 immune responses. Here we summarize recent work demonstrating the role of this cytokine in promoting allergy, and discuss its potential producer and responder cells during allergic inflammation. IL-25 thus serves as a novel target for pharmaceutical intervention of allergic asthma disease.
KeywordsAllergic Disease Allergy Clin Immunol Lung Epithelial Cell Allergic Inflammation Allergic Airway Disease
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- 20.Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE, McKenzie AN (2006) Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med 203: 1105–1116PubMedCrossRefGoogle Scholar