IL-25, another promoter of allergy

  • Pornpimon Angkasekwinai
  • Chen Dong
Part of the Progress in Inflammation Research book series (PIR)


Although there have been significant insights into the mechanism underlying the initiation of type 1 immune response, how type 2-mediated pathology especially allergic diseases is developed remains unclear. Cytokine environment is important in shaping and initiating Th2 responses. IL-25, also called IL-17E, belongs to the IL-17 family but, unlike other IL-17 cytokine members, possesses a unique function in regulating type 2 immune responses. Here we summarize recent work demonstrating the role of this cytokine in promoting allergy, and discuss its potential producer and responder cells during allergic inflammation. IL-25 thus serves as a novel target for pharmaceutical intervention of allergic asthma disease.


Allergic Disease Allergy Clin Immunol Lung Epithelial Cell Allergic Inflammation Allergic Airway Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Pornpimon Angkasekwinai
    • 1
    • 2
  • Chen Dong
    • 1
  1. 1.Department of Immunology, MD Anderson Cancer Center and Graduate School of Biomedical ScienceUniversity of TexasHoustonUSA
  2. 2.Faculty of Allied Health SciencesThammasat UniversityPathum-thaniThailand

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