Other sources of IL-17: Invariant natural killer T cells

  • Marie-Laure Miche
  • Maria C. Leite-de-Moraes
Part of the Progress in Inflammation Research book series (PIR)


Interleukin-17 (IL-17) plays a major role in various models of immune-mediated tissue injury, including organ-specific autoimmunity, allergic disorders and microbial infections. Th17 cells are currently the most thoroughly characterized source of IL-17 credited for causing and sustaining the tissue damage mediated by this cytokine. Similarly to their Th1 and Th2 counterpart, Th17 cells depend on specific factors for their differentiation from naïve T cell precursors, before acquiring their typical cytokine profile. However, this is not the case for all IL-17-producing cells, particularly for a subset of invariant natural killer T cells, termed iNKT17, which are ready to produce this cytokine immediately upon stimulation, in keeping with their capacity to intervene during early stages of the inflammatory response.


Th17 Cell Allergic Asthma iNKT Cell Experimental Allergic Encephalomyelitis Airway Neutrophilia 


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Marie-Laure Miche
    • 1
  • Maria C. Leite-de-Moraes
    • 1
  1. 1.CNRS (Centre National de la Recherche Scientifique)UMR (Unité Mixte de Recherche) 8147, Faculté de Médecine René Descartes, Paris V, Hôpital NeckerParis, Cedex 15France

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