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Th 17 Cells: Role in Inflammation and Autoimmune Disease pp 201–209Cite as

IL-17 cytokines in asthma

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The current chapter scrutinizes the published evidence from humans that IL-17, as well as more recently discovered members of the IL-17 cytokine family, may be involved in the pathogenesis of asthma by contributing to the mobilization of granulocytes. Whereas there is indicative published evidence from patients with asthma arguing for IL-17 and, to lesser degree, for IL-17F, involvement, the current case for the other IL-17 cytokines remains weak in terms of clinical evidence. For the future, there is a need for more studies on human patients with well-characterized phenotypes and consistent medication, to more firmly establish the pathogenic role of IL-17 cytokines in asthma and the pharmacotherapeutic potential of targeting these intriguing molecules.

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Author information

Authors and Affiliations

  1. Lung Immunology Group, Department of Internal Medicine/Respiratory Medicine and Allergology, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden

    Anders Lindén

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  1. Anders Lindén
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Editor information

Editors and Affiliations

  1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, 45071, Orléans, France

    Valérie Quesniaux  & Bernhard Ryffel  & 

  2. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

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© 2009 Birkhäuser Verlag Basel/Switzerland

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Lindén, A. (2009). IL-17 cytokines in asthma. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_17

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  • DOI: https://doi.org/10.1007/978-3-7643-8681-8_17

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8680-1

  • Online ISBN: 978-3-7643-8681-8

  • eBook Packages: MedicineMedicine (R0)

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