IL-17 cytokines in asthma

  • Anders Lindén
Part of the Progress in Inflammation Research book series (PIR)


The current chapter scrutinizes the published evidence from humans that IL-17, as well as more recently discovered members of the IL-17 cytokine family, may be involved in the pathogenesis of asthma by contributing to the mobilization of granulocytes. Whereas there is indicative published evidence from patients with asthma arguing for IL-17 and, to lesser degree, for IL-17F, involvement, the current case for the other IL-17 cytokines remains weak in terms of clinical evidence. For the future, there is a need for more studies on human patients with well-characterized phenotypes and consistent medication, to more firmly establish the pathogenic role of IL-17 cytokines in asthma and the pharmacotherapeutic potential of targeting these intriguing molecules.


Severe Asthma Allergy Clin Immunol Allergic Asthma Exhale Breath Condensate Human Bronchial Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Anders Lindén
    • 1
  1. 1.Lung Immunology Group, Department of Internal Medicine/Respiratory Medicine and AllergologyInstitute of Medicine, Sahlgrenska Academy at the University of GothenburgGöteborgSweden

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