IL-17 and Th17 cells in rheumatoid arthritis
IL-17 was identified in 1995/96 as a T cell-derived cytokine with effects on inflammation and neutrophil activation. Rheumatoid arthritis has emerged as the most studied situation to justify the selection of IL-17 as a therapeutic target. By interacting with other proinflammatory cytokines, IL-17 was found to induce bone and cartilage destruction. In 2006, the precise cell source of IL-17 was identified in the mouse. These cells were named Th17 and their key role was demonstrated in various situations associated with inflammation and matrix destruction. These new findings confirmed and extended the results previously obtained following the identification of IL-17 as a T cell-derived cytokine. At the same time, additional information was obtained on the other members of the IL-17 family and on the structure of the IL-17 receptor complex. Such knowledge has further extended the choice of possible modalities to control IL-17.
KeywordsRheumatoid Arthritis Th17 Cell Rheumatoid Arthritis Synovium Th17 Pathway Matrix Destruction
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