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IL-23 orchestrates the switch from tumor immune surveillance to tumor-promoting inflammation

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Th 17 Cells: Role in Inflammation and Autoimmune Disease

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Human tumor cells acquire and accumulate mutations and transcriptional changes that provide growth and survival signals and a tumor-promoting microenvironment. Over the last few decades it has become clear that the mammalian immune system is able to recognize these genetic and epigenetic changes, and that T cells specific to oncogenes and oncofetal antigens are present in human cancer patients and their tumors. Immune-mediated inflammation, however, increases tumor incidence and progression. Epidemiologically, inflammatory disease-inducing cytokines have also been linked to tumor progression. However, the nature of the pro-inflammatory T cells that control the chronic inflammatory response, and their regulation by cytokines like IL-23, only became known recently. This review attempts to summarize our knowledge of pro-inflammatory T cells in cancer, and the cytokines that contribute to the deregulation of tumor-promoting inflammation and its inhibitory consequences on the tumor cell elimination by cytotoxic T cells.

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Author information

Authors and Affiliations

  1. Schering-Plough Biopharma (formerly DNAX), 901 California Avenue, Palo Alto, CA, 94303, USA

    Martin Oft

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  1. Martin Oft
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Editors and Affiliations

  1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, 45071, Orléans, France

    Valérie Quesniaux  & Bernhard Ryffel  & 

  2. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

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© 2009 Birkhäuser Verlag Basel/Switzerland

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Oft, M. (2009). IL-23 orchestrates the switch from tumor immune surveillance to tumor-promoting inflammation. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_14

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  • DOI: https://doi.org/10.1007/978-3-7643-8681-8_14

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8680-1

  • Online ISBN: 978-3-7643-8681-8

  • eBook Packages: MedicineMedicine (R0)

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