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Th17 cells in organ transplantation

  • Ye Chen
  • Kathryn J. Wood
Part of the Progress in Inflammation Research book series (PIR)

Abstract

A newly discovered subset of T helper cells, Th17 cells, has been implicated in a number of models of autoimmunity. However, their role in transplantation remains undefined. This is despite studies showing a link between IL-17, a cytokine secreted by Th17 cells, and acute allograft rejection. This chapter summarises current evidence for a role of Th17 cells in transplant rejection, tolerance and ischaemia reperfusion injury.

Keywords

Th17 Cell Experimental Autoimmune Encephalomyelitis Ischaemia Reperfusion Injury Allograft Rejection Delay Graft Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Ye Chen
    • 1
  • Kathryn J. Wood
    • 2
  1. 1.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK
  2. 2.Transplantation Research Immunology Group, Nuffield Department of SurgeryUniversity of OxfordOxfordUK

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