The role of IL-17 in experimental autoimmune myocarditis

  • Alan Valaperti
  • Urs Eriksson
Part of the Progress in Inflammation Research book series (PIR)


Experimental autoimmune myocarditis (EAM) represents a CD4+ T cell-mediated mouse model of inflammatory heart disease. Induction of autoreactive, heart-specific CD4+ T cells depends on Toll-like receptor-mediated activation of self-antigen-loaded antigen-presenting cells beyond a genetically determined threshold. Recent findings suggest that the expansion of a specific subset of heart-pathogenic CD4+ cells characterized by IL-17 production is required for disease development. Accordingly, cytokines promoting Th17 CD4+ expansion, such as IL-6, IL-23, and IL-1 are key players in EAM. Understanding the specific role of distinct cytokines during induction and progression of EAM expands our knowledge on the mechanisms of inflammatory heart diseases and contributes to the development of novel treatment strategies in the future.


Dendritic Cell Autoimmune Myocarditis Experimental Autoimmune Myocarditis Cardiac Inflammation Adoptive Transfer Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Alan Valaperti
    • 1
    • 2
  • Urs Eriksson
    • 1
    • 2
    • 3
  1. 1.Experimental Critical Care Medicine, Department of BiomedicineUniversity HospitalBasleSwitzerland
  2. 2.Cardiovascular Research, Institute of PhysiologyUniversity Zürich-IrchelZürichSwitzerland
  3. 3.Department of CardiologyUniversity HospitalZürichSwitzerland

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