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Introduction

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Th 17 Cells: Role in Inflammation and Autoimmune Disease

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

The identification of IL-17A and Th17 cells have modified the established Th1, Th2 paradigm, led to the definition of a new CD3+CD4+ Th17 cell subset and introduced a new paradigm to explain the origin of several autoimmune events. However, this paradigm shift tended also to identify the effects of IL-17A with those of Th17 cells and vice versa. This view might be insufficient to explain the role of IL-17A in several infection and autoimmune models. IL-17A is in fact produced by several other cell types involved in host defense, autoimmunity and inflammation. Overall, we favor the hypothesis that in an early phase of the immune response γ δ T cells are directly involved in the production of IL-17A. This is followed by the involvement of αβ Th17 cells. We cannot exclude that, in some human chronic diseases, other cell types like macrophages or astrocytes may also acquire the capacity to produce IL-17A and be involved in pathology.

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Authors and Affiliations

  1. Novartis Institutes for Biomedical Research, WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

  2. UMR6218 Molecular Immunology and Embryology, University of Orleans and CNRS, 45071, Orleans, France

    Bernhard Ryffel & Valérie Quesniaux

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  1. Franco Di Padova
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  2. Bernhard Ryffel
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  1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, 45071, Orléans, France

    Valérie Quesniaux  & Bernhard Ryffel  & 

  2. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, 4002, Basel, Switzerland

    Franco Di Padova

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Di Padova, F., Ryffel, B., Quesniaux, V. (2009). Introduction. In: Quesniaux, V., Ryffel, B., Di Padova, F. (eds) Th 17 Cells: Role in Inflammation and Autoimmune Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8681-8_1

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  • DOI: https://doi.org/10.1007/978-3-7643-8681-8_1

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8680-1

  • Online ISBN: 978-3-7643-8681-8

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