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Introduction

  • Franco Di Padova
  • Bernhard Ryffel
  • Valérie Quesniaux
Part of the Progress in Inflammation Research book series (PIR)

Abstract

The identification of IL-17A and Th17 cells have modified the established Th1, Th2 paradigm, led to the definition of a new CD3+CD4+ Th17 cell subset and introduced a new paradigm to explain the origin of several autoimmune events. However, this paradigm shift tended also to identify the effects of IL-17A with those of Th17 cells and vice versa. This view might be insufficient to explain the role of IL-17A in several infection and autoimmune models. IL-17A is in fact produced by several other cell types involved in host defense, autoimmunity and inflammation. Overall, we favor the hypothesis that in an early phase of the immune response γ δ T cells are directly involved in the production of IL-17A. This is followed by the involvement of αβ Th17 cells. We cannot exclude that, in some human chronic diseases, other cell types like macrophages or astrocytes may also acquire the capacity to produce IL-17A and be involved in pathology.

Keywords

Th17 Cell Experimental Autoimmune Encephalomyelitis iNKT Cell Programme Death Ligand Herpesvirus Saimiri 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Franco Di Padova
    • 1
  • Bernhard Ryffel
    • 2
  • Valérie Quesniaux
    • 2
  1. 1.Novartis Institutes for Biomedical ResearchBaselSwitzerland
  2. 2.UMR6218 Molecular Immunology and EmbryologyUniversity of Orleans and CNRSOrleansFrance

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