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Application of natural product-inspired diversity-oriented synthesis to drug discovery

  • Lisa A. Marcaurelle
  • Charles W. Johannes
Part of the Progress in Drug Research book series (PDR, volume 66)

Abstract

Natural products have played a critical role in the identification of numerous medicines. Synthetic organic chemistry and combinatorial chemistry strategies such as diversity-oriented synthesis (DOS) have enabled the synthesis of natural product-like compounds. The combination of these approaches has both improved the desired biological properties of natural products as well as the identification of novel compounds. Diversity concepts and strategies to access novel compounds inspired by natural products will be reviewed.

Keywords

Drug Discovery SHIKIMIC Acid Nicotine Agonist Allylic Alcohol Chemical Genetic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag, Basel (Switzerland) 2008

Authors and Affiliations

  • Lisa A. Marcaurelle
    • 1
  • Charles W. Johannes
    • 2
  1. 1.Broad Institute of Harvard and MITCambridgeUSA
  2. 2.Infinity Pharmaceuticals, Inc.CambridgeUSA

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