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Matrix Metalloproteinases in Tissue Remodelling and Inflammation pp 153–163Cite as

Extracellular matrix remodelling and matrix metalloproteinases in the liver

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

A variety of exogenous and endogenous agents, e.g., toxic compounds, drugs, pathogens, are responsible for acute and liver injuries which may lead to inflammation and fibrosis and impair hepatocyte functions. In inflamed and fibrotic livers, extracellular matrix remodelling is a complex mechanism of synthesis and degradation of matrix components, namely collagens, non-collagenous glycoproteins and proteoglycans. Fibrolysis is the result of the activation of proteases, among them matrix metalloproteinases, which cleave matrix components and release (poly)-peptide modules with specific biological activities. The dynamic turnover of extracellular matrix is regulated by cytokines and other soluble factors. Depicting these mechanisms opens the path to the identification of biomarkers and targeted drugs for the reversion of inflamed/fibrotic scar towards a normal architecture and the restoration of normal liver functions.

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Authors and Affiliations

  1. INSERM, U-620, Detoxication and Tissue Repair Unit, University of Rennes I, 2 av. Léon Bernard, 35043, Rennes, France

    Bruno Clément

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  1. Bruno Clément
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Editors and Affiliations

  1. INSERM U620 Faculté des Sciences Pharmaceutiques et Biologique, Université de Rennes 1, Avenue du Professeur Léon Bernard 2, 35043, Rennes CX, France

    Vincent Lagente  & Elisabeth Boichot  & 

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Clément, B. (2008). Extracellular matrix remodelling and matrix metalloproteinases in the liver. In: Lagente, V., Boichot, E. (eds) Matrix Metalloproteinases in Tissue Remodelling and Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8585-9_9

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