MMP roles in the initiation and progression of cardiac remodeling leading to congestive heart failure

  • Jing Lin
  • Merry L. Lindsey
Part of the Progress in Inflammation Research book series (PIR)


Cardiac remodeling is induced by a multitude of stimuli, including myocardial infarction, pressure and/or volume overload, and genetics; and involves matrix metalloproteinases (MMPs) every step of the way [1]. While cardiac remodeling is initially a compensatory response, the transition to adverse remodeling frequently culminates in the development of congestive heart failure (CHF), and CHF is a significant contributor to cardiovascular morbidity and mortality rates. This chapter will define cardiac remodeling, describe MMP-dependent mechanisms that stimulate the remodeling process, and explore future directions and therapeutic potentials in terms of MMP inhibition. We will focus on the primary diseases that stimulate cardiac remodeling in humans, namely myocardial infarction and hypertension. Understanding how cardiac remodeling evolves from an initially beneficial mechanism to a maladaptive event and how MMPs influence these stages will potentially provide us with markers to predict adverse events in the clinic.


Congestive Heart Failure Connective Tissue Growth Factor Pressure Overload Cardiac Fibroblast Congestive Heart Failure Patient 


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Jing Lin
    • 1
  • Merry L. Lindsey
    • 1
  1. 1.Medicine/CardiologyUniversity of Texas Health Science CenterSan AntonioUSA

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