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Anti-inflammatory properties of MMP inhibitors in experimental models of chronic obstructive pulmonary disease and lung inflammation

  • Catherine le Quément
  • Vincent Lagente
  • Isabelle Guénon
  • Valeria Muzio
  • Jean-Yves Gillon
  • Elisabeth Boichot
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Matrix metalloproteinases (MMPs) are a group of proteases known to regulate the turnover of extracellular matrix and thus are suggested to be important in the process of lung disease associated with tissue remodelling. Furthermore, the concept that modulation of airway remodelling including excessive proteolysis damage of the tissue, may be of interest as a basis for future treatment. Among the metalloproteinases (MMPs) family, macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodelling processes in chronic obstructive pulmonary disease including emphysema. Recent studies using broad spectrum MMP or dual MMP-9/MMP-12 inhibitors have demonstrated a reduction in both inflammatory process and airspace enlargement in lung tissue. In the present chapter, we also report the inhibitory activity of a new MMP-9/MMP-12 inhibitor, AS112108, on acute lung inflammatory processes induced by cigarette smoke.

Keywords

Chronic Obstructive Pulmonary Disease Cigarette Smoke Chronic Obstructive Pulmonary Disease Patient Respir Crit Cigarette Smoke Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Catherine le Quément
    • 1
  • Vincent Lagente
    • 1
  • Isabelle Guénon
    • 1
  • Valeria Muzio
    • 2
  • Jean-Yves Gillon
    • 3
  • Elisabeth Boichot
    • 1
  1. 1.INSERM U620, Faculté de PharmacieUniversité de Rennes 1RennesFrance
  2. 2.LCG-RBMIstituto di Ricerche Biomediche “Antoine Marxer”Colleretto GiacosaItaly
  3. 3.Merck-Serono International S.A.Geneva 20Switzerland

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