Course and outcome of bipolar disorder — focusing on depressive aspects

  • Tamas Treuer
  • Mauricio Tohen
Part of the Milestones in Drug Therapy book series (MDT)


The prognosis of an illness is perhaps relatively more valuable in psychiatry than in other therapeutic areas, because the lack of a laboratory-based diagnostic test and poor biological markers in mental disorders limit outcome predictions based mostly on the information from the psychiatric interview and examination. This is particularly true in bipolar disorder. In this chapter the authors summarize the main factors predicting course and outcome in bipolar disorder with a focus on depressive symptoms. The natural course, the impact of first episode, the impact of depressive phase, cycle length, onset, age, gender, type of illness, personality traits and temperament, co-morbidity, family history, life events, and outcome features will be reviewed. Conceptual models and their prognostic value will be discussed as well.


Bipolar Disorder Bipolar Depression Mixed Episode Bipolar Spectrum Disorder Bipolar Disor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag/Switzerland 2009

Authors and Affiliations

  • Tamas Treuer
    • 1
  • Mauricio Tohen
    • 2
  1. 1.Area Medical Center ViennaEli Lilly & CompanyBudapestHungary
  2. 2.Lilly Research LaboratoriesIndianapolis, and McLean Hospital, Harvard Medical SchoolBelmontUSA

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