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Serotonin and Sleep: Molecular, Functional and Clinical Aspects pp 155–182Cite as

Molecular biology of 5-HT receptors

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Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its effects are mediated by as many as 13 distinct G protein-coupled receptors and several ligand-gated ion channels (5-HT3). These receptors are divided into seven distinct classes (5-HT1 to 5-HT7) largely on the basis of their structural, transductional and operational characteristics. While this degree of physical diversity clearly underscores the physiological importance of serotonin, evidence for an even greater degree of operational diversity continues to emerge.

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  1. Nervous System Research, WSJ.386.745, Novartis Institute for Biomedical Research, 4002, Basel, Switzerland

    Jason Hannon & Daniel Hoyer

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  1. Pharmacology and Therapeutics, School of Medicine, Clinics Hospital, Montevideo, 11300, Uruguay

    Jaime M. Monti

  2. Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 West 168th Street - Rm # BB813, New York, NY, 10032, USA

    S. R. Pandi-Perumal

  3. Green Hall, Program in Neuroscience, Princeton University, Princeton, NJ, 08540, USA

    Barry L. Jacobs

  4. Psychopharmacology Unit, Dorothy Hodgkin Building Whitson Street, Bristol, BS1 3NY, UK

    David J. Nutt

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Hannon, J., Hoyer, D. (2008). Molecular biology of 5-HT receptors. In: Monti, J.M., Pandi-Perumal, S.R., Jacobs, B.L., Nutt, D.J. (eds) Serotonin and Sleep: Molecular, Functional and Clinical Aspects. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8561-3_6

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