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Hepatitis A infection

  • Manfred H. Wolff
  • Axel Schmidt
Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)

Abstract

Hepatitis A is a ubiquitous disease of man with acute, self-limiting liver inflammation and a low mortality rate, also known as ‘traveller’s hepatitis’, ‘hepatitis epidemica’, and ‘infectious hepatitis’. The causative infectious agent is the hepatitis A virus belonging to the family of the Picornaviridae, genus Hepatovirus. The route of transmission is mainly faecal-oral. Hepatitis A is an acute hepatitis that does not become chronic like hepatitis B and C, and it is no risk factor for the development of hepatocellular malignancies. The severity of clinical manifestation is often age related with predominantly inapparent infection in young individuals to more severe courses of infection in the adults and elderly. Hepatitis A is most predominant in countries with poor hygienic conditions and is therefore sometimes attributed as ‘traveller’s hepatitis’. Potent vaccines for protection and disease prevention are available and the ambitious medical aim — eradicating HAV by aggressive vaccination strategies — appears realistic.

Keywords

Acute Hepatitis Peracetic Acid Intrahepatic Cholestasis Tissue Tropism Human Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Manfred H. Wolff
    • 1
  • Axel Schmidt
    • 2
  1. 1.Institute of Microbiology and VirologyPrivate University of Witten/HerdeckeWittenGermany
  2. 2.Faculty of MedicinePrivate University of Witten/HerdeckeWittenGermany

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