Skip to main content
SpringerLink
Log in

Hepatitis in dogs

  • Chapter
Comparative Hepatitis

Part of the book series: Birkhäuser Advances in Infectious Diseases ((BAID))

  • 805 Accesses

Abstract

Liver diseases are a major focus of research in the Faculty of Veterinary Medicine. In a clinical population 1% of the dogs has a form of hepatitis. There are several aspects of canine hepatitis which make comparison with human hepatitis very useful. As a whole, liver diseases and especially different forms of hepatitis in dogs develop highly similar to human hepatitis (fulminant, acute, chronic). This makes dog diseases interesting to study important aspects in the pathogenesis of the disease. We have shown that in humans and dogs identical processes with respect to formation of fibrosis, regeneration, stem cell activation, and oxidative damage occur. In most aspects identical pathogenesis and pathophysiology of canine and human hepatitis make these spontaneous dog diseases ideal models to study the effect of new modes of intervention to stimulate regeneration and reduce or prevent cirrhosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rothuizen J, Bunch SE, Charles JA, Cullen JM, Desmet VJ, Szatmari V, Twedt DC, van den Ingh TSGAM, van Winkle TJ, Washabau RJ, WSAVA Liver Standardization Group (2006) WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Disease. Saunders-Elsevier, Edinburgh

    Google Scholar 

  2. Decaro N, Campolo M, Elia G, Buonavoglia D, Colaianni ML, Lorusso A, Mari V, Buonavoglia C (2007) Infectious canine hepatitis: an “old” disease reemerging in Italy. Res Vet Sci 83: 269–273

    Article  PubMed  CAS  Google Scholar 

  3. Solleveld HA, van Zwieten MJ, van Kessel AC, Heidt PJ (1978) Nalidixic acid intoxication in two pregnant bitches. Tijdschr Diergeneeskd 103: 899–906

    PubMed  CAS  Google Scholar 

  4. Duffell SJ (1975) Letter: Unexpected reaction to nalidixic acid. Vet Rec 96: 188

    PubMed  CAS  Google Scholar 

  5. Trepanier LA (2004) Idiosyncratic toxicity associated with potentiated sulfonamides in the dog. J Vet Pharmacol Ther 27: 129–138

    Article  PubMed  CAS  Google Scholar 

  6. Twedt DC, Diehl KJ, Lappin MR, Getzy DM (1997) Association of hepatic necrosis with trimethoprim sulfonamide administration in 4 dogs. J Vet Intern Med 11: 20–23

    PubMed  CAS  Google Scholar 

  7. Ghneim GS, Viers JH, Chomel BB, Kass PH, Descollonges DA, Johnson ML (2007) Use of a case-control study and geographic information systems to determine environmental and demographic risk factors for canine leptospirosis. Vet Res 38: 37–50

    Article  PubMed  Google Scholar 

  8. Moore GE, Guptill LF, Glickman NW, Caldanaro RJ, Aucoin D, Glickman LT (2006) Canine leptospirosis, United States, 2002–2004. Emerg Infect Dis 12: 501–503

    PubMed  Google Scholar 

  9. Greenlee JJ, Alt DP, Bolin CA, Zuerner RL, Andreasen CB (2005) Experimental canine leptospirosis caused by Leptospira interrogans serovars pomona and bratislava. Am J Vet Res 66: 1816–1822

    Article  PubMed  Google Scholar 

  10. Faucher JF, Hoen B, Estavoyer JM (2004) The management of leptospirosis. Expert Opin Pharmacother 5: 819–827

    Article  PubMed  CAS  Google Scholar 

  11. Shih JL, Keating JH, Freeman LM, Webster CR (2007) Chronic hepatitis in Labrador Retrievers: clinical presentation and prognostic factors. J Vet Intern Med 21: 33–39

    Article  PubMed  Google Scholar 

  12. Watson PJ (2004) Chronic hepatitis in dogs: a review of current understanding of the aetiology, progression, and treatment. Vet J 167: 228–241

    Article  PubMed  CAS  Google Scholar 

  13. Rothuizen J (2004) Canine chronic liver disease: where are we now? Four pointers for future research. Vet J 167: 219

    Article  PubMed  Google Scholar 

  14. Boisclair J, Dore M, Beauchamp G, Chouinard L, Girard C (2001) Characterization of the inflammatory infiltrate in canine chronic hepatitis. Vet Pathol 38: 628–635

    Article  PubMed  CAS  Google Scholar 

  15. Vitral CL, Pinto MA, Lewis-Ximenez LL, Khudyakov YE, dos Santos DR, Gaspar AM (2005) Serological evidence of hepatitis E virus infection in different animal species from the Southeast of Brazil. Mem Inst Oswaldo Cruz 100: 117–122

    Article  PubMed  Google Scholar 

  16. Boomkens SY, Slump E, Egberink HF, Rothuizen J, Penning LC (2005) PCR screening for candidate etiological agents of canine hepatitis. Vet Microbiol 108: 49–55

    Article  PubMed  CAS  Google Scholar 

  17. Boomkens SY, Penning LC, Egberink HF, van den Ingh TS, Rothuizen J (2004) Hepatitis with special reference to dogs. A review on the pathogenesis and infectious etiologies, including unpublished results of recent own studies. Vet Q 26: 107–114

    PubMed  CAS  Google Scholar 

  18. Morris TQ, Gocke DJ (1972) Modified acute canine viral hepatitis-a model for physiologic study. Proc Soc Exp Biol Med 139: 32–39

    PubMed  CAS  Google Scholar 

  19. Gocke DJ, Preisig R, Morris TQ, McKay DG, Bradley SE (1967) Experimental viral hepatitis in the dog: production of persistent disease in partially immune animals. J Clin Invest 46: 1506–1517

    PubMed  CAS  Google Scholar 

  20. Rolfe, Twedt (1995) Copper-associated hepatopathies in dogs. Vet Clin N Am Small Animal Practice 2: 399–417

    Google Scholar 

  21. Hoffmann G, van den Ingh TS, Bode P, Rothuizen J (2006) Copper-associated chronic hepatitis in Labrador Retrievers. J Vet Intern Med 20: 856–861

    Article  PubMed  CAS  Google Scholar 

  22. Mandigers, van den Ingh, Bode, Teske E, Rothuizen J (2004) Association between liver copper concentration and subclinical hepatitis in Doberman Pinschers. J Vet Internal Med 18: 647–650

    Article  CAS  Google Scholar 

  23. Speeti, Eriksson, Saari, Westermarck (1998) Lesions of subclinical doberman hepatitis. Vet Pathology 35: 361–369

    Article  CAS  Google Scholar 

  24. Spee B, Arends B, van den Ingh TS, Penning LC, Rothuizen J (2006) Copper metabolism and oxidative stress in chronic inflammatory and cholestatic liver diseases in dogs. J Vet Intern Med 20: 1085–1092

    Article  PubMed  Google Scholar 

  25. Mandigers PJ, Bode P, van Wees AM, van den Brom WE, van den Ingh TS, Rothuizen J (2007) Hepatic (64)Cu excretion in Dobermanns with subclinical hepatitis. Res Vet Sci 83: 204–209

    Article  PubMed  CAS  Google Scholar 

  26. Mandigers PJ, van den Ingh TS, Bode P, Rothuizen J (2005) Improvement in liver pathology after 4 months of D-penicillamine in 5 doberman pinschers with subclinical hepatitis. J Vet Intern Med 19: 40–43

    Article  PubMed  CAS  Google Scholar 

  27. Spee B, Arends B, van Wees AM, Bode P, Penning LC, Rothuizen J (2007) Functional consequences of RNA interference targeting COMMD1 in a canine hepatic cell line in relation to copper toxicosis. Anim Genet 38: 168–170

    Article  PubMed  CAS  Google Scholar 

  28. Favier RP, Spee B, Penning LC, Brinkhof B, Rothuizen J (2005) Quantitative PCR method to detect a 13-kb deletion in the MURR1 gene associated with copper toxicosis and HIV-1 replication. Mamm Genome 16: 460–463

    Article  PubMed  CAS  Google Scholar 

  29. Haywood S, Rutgers HC, Christian MK (1988) Hepatitis and copper accumulation in Skye terriers. Vet Pathology 25: 408–414

    Article  CAS  Google Scholar 

  30. Thornburg LP, Rottinghaus G, Dennis G, Crawford S (1996) The relationship between hepatic copper content and morphologic changes in the liver of West Highland White Terriers. Vet Pathology 33: 656–661

    CAS  Google Scholar 

  31. Thornburg LP, Rottinghaus G, Koch J, Hause WR (1983) High liver copper levels in Doberman Pinschers with subacute hepatitis. J Am Animal Hosp Assoc 20: 1003–1005

    Google Scholar 

  32. Thornburg LP, Shaw D, Dolan M, Raisbeck M, Crawford S, Dennis GL, Olwin DB (1986) Hereditary copper toxicosis in West Highland White terriers. Vet Pathology 23: 148–154

    CAS  Google Scholar 

  33. Webb CB, Twedt DC, Meyer DJ (2002) Copper-associated liver disease in Dalmatians: a review of 10 dogs (1998–2001). J Vet Internal Med 16: 665–668

    Article  Google Scholar 

  34. Forman OP, Boursnell ME, Dunmore BJ, Stendall N, van den Sluis B, Fretwell N, Jones C, Wijmenga C, Rothuizen J, van Oost BA et al (2005) Characterization of the COMMD1 (MURR1) mutation causing copper toxicosis in Bedlington terriers. Anim Genet 36: 497–501

    PubMed  CAS  Google Scholar 

  35. Mandigers PJ, van den Ingh TS, Bode P, Rothuizen J (2005) Improvement in liver pathology after 4 months of D-penicillamine in 5 doberman pinschers with subclinical hepatitis. J Vet Intern Med 19: 40–43

    Article  PubMed  CAS  Google Scholar 

  36. Spee B, Arends B, van den Ingh TS, Roskams T, Rothuizen J, Penning LC (2007) Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis. Comp Hepatol 31; 6: 8–14

    Article  CAS  Google Scholar 

  37. Spee B, Arends B, van den Ingh TS, Brinkhof B, Nederbragt H, Ijzer J, Roskams T, Penning LC, Rothuizen J (2006) Transforming growth factor beta-1 signalling in canine hepatic diseases: new models for human fibrotic liver pathologies. Liver Int 26: 716–725

    Article  PubMed  CAS  Google Scholar 

  38. Spee B, Penning LC, van den Ingh TS, Arends B, IIzer J, van Sluijs FJ, Rothuizen J (2005) Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment. Comp Hepatol 4: 7–17

    Article  PubMed  CAS  Google Scholar 

  39. Ijzer J, Roskams T, Molenbeek RF, Ultee T, Penning LC, Rothuizen J, van den Ingh TS (2006) Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver. Comp Hepatol 5: 7–13

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University Utrecht, Yalelaan 108, 3508 TD, Utrecht, The Netherlands

    Jan Rothuizen

Authors
  1. Jan Rothuizen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Bayer AG, 51368, Leverkusen, Germany

    Olaf Weber

  2. Institute of Virology, Technical University Munich/Helmholtz Center Munich, Trogerstr. 30, 81675, München, Germany

    Ulrike Protzer

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Rothuizen, J. (2008). Hepatitis in dogs. In: Weber, O., Protzer, U. (eds) Comparative Hepatitis. Birkhäuser Advances in Infectious Diseases. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8558-3_11

Download citation

Publish with us

Policies and ethics

Search

Navigation