Gene-environment interactions in occupational asthma
This chapter reviews the existing knowledge regarding gene-environment interactions in occupational asthma. So far, studies have been conducted on relatively small samples, considering workers exposed to specific hazards such as isocyanates or red cedar. HLA class II, genes in the antioxidant defense, and more recently genes in the innate immunity pathway have been studied. As yet, few interactions have been demonstrated; however, the development of large-scale genetic studies of asthma will likely change the situation. Two types of approach can be developed based on testing hypotheses (candidate interactions) or in searching interactions with genes of yet-unknown function that may be evidenced through genome-wide associations. Current challenges concern the improvement of phenotypic and environmental characterization and setting up interdisciplinary research to understand the determinants of asthma. Building large international consortia on asthma with data on occupational exposure is warranted.
KeywordsOccupational Exposure Allergy Clin Immunol Respir Crit Occupational Asthma Acid Anhydride
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