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The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects

  • Chapter
Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The facial skeleton supports a diverse variety of functions, and thus its morphology is equally diverse. In addition, the facial bones are altered from normal by a wide variety of processes including trauma, infection, cysts, neoplasms, congenital defects, developmental deformities, periodontal disease, tooth extraction, atrophy, and edentulous bone loss. The potential for successful reconstruction of these defects is based upon appropriate host graft interactions. Host characteristics that may influence success include the patient’s metabolic status, age, tissue vascularity, availability of stem cells, and a host site uncompromised by infection or excessive scar. Graft characteristics should include a lack of immune response, osteogenic potential, appropriate geometry to support vascular and cellular migration, osteoconduction, and a chemotactic and osteoinductive influence on host stem cells, and it must mature to sustain physiological forces.

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Author information

Authors and Affiliations

  1. Uniersity Oral and Maxillofacial Surgery, 7482 Waterside Crossing Blvd, Charlotte, NC, 28037, USA

    Daniel B. Spagnoli

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  1. Daniel B. Spagnoli
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Editors and Affiliations

  1. School of Medicine Inst. Anatomy Drago Perovic, University of Zagreb, Salata 11, 10000, Zagreb, Croatia

    Slobodan Vukicevic

  2. Genzyme Corporation, One Mountain Road, Framingham, MA, 01701-9322, USA

    Kuber T. Sampath

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© 2008 Birkhäuser Verlag Basel/Switzerland

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Spagnoli, D.B. (2008). The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects. In: Vukicevic, S., Sampath, K.T. (eds) Bone Morphogenetic Proteins: From Local to Systemic Therapeutics. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8552-1_4

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  • DOI: https://doi.org/10.1007/978-3-7643-8552-1_4

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8551-4

  • Online ISBN: 978-3-7643-8552-1

  • eBook Packages: MedicineMedicine (R0)

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