The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects

  • Daniel B. Spagnoli
Part of the Progress in Inflammation Research book series (PIR)


The facial skeleton supports a diverse variety of functions, and thus its morphology is equally diverse. In addition, the facial bones are altered from normal by a wide variety of processes including trauma, infection, cysts, neoplasms, congenital defects, developmental deformities, periodontal disease, tooth extraction, atrophy, and edentulous bone loss. The potential for successful reconstruction of these defects is based upon appropriate host graft interactions. Host characteristics that may influence success include the patient’s metabolic status, age, tissue vascularity, availability of stem cells, and a host site uncompromised by infection or excessive scar. Graft characteristics should include a lack of immune response, osteogenic potential, appropriate geometry to support vascular and cellular migration, osteoconduction, and a chemotactic and osteoinductive influence on host stem cells, and it must mature to sustain physiological forces.


Periodontal Disease Recombinant Human Bone Morphogenetic Protein Absorbable Collagen Sponge Palate Repair Medial Soft Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Daniel B. Spagnoli
    • 1
  1. 1.Uniersity Oral and Maxillofacial SurgeryCharlotteUSA

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