Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results

  • William F. McKay
  • Steven M. Peckham
  • Jeffrey M. Badura
Part of the Progress in Inflammation Research book series (PIR)


Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been commercially available in the United States since July 2002 (INFUSE® Bone Graft/LTCAGE ®Lumbar Tapered Fusion Device, Medtronic, Inc., Memphis, TN). It was initially approved for use in interbody spinal fusions inside a threaded titanium interbody fusion device. Since then, it has been approved for two additional clinical indications: fresh tibial fractures and certain oral maxillofacial procedures (sinus elevation and extraction sockets). The approvals were based on Level I prospective, randomized clinical trials involving the absorbable collagen sponge (ACS) carrier and rhBMP-2 at a concentration of 1.5 mg/mL.


Interbody Fusion Tibial Fracture Fusion Device Extraction Socket Recombinant Human Bone 
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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • William F. McKay
    • 1
  • Steven M. Peckham
    • 1
  • Jeffrey M. Badura
    • 1
  1. 1.Medtronic, Inc.MemphisUSA

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