Bone morphogenetic proteins in cartilage biology

  • Susan Chubinskaya
  • Mark Hurtig
  • David C. Rueger
Part of the Progress in Inflammation Research book series (PIR)


Cartilage repair and regeneration is a major obstacle in orthopedic medicine. The importance is enormous since osteoarthritis (OA) is a major cause of disability among the adult population in the United States and degenerative disc disease (DDD) is responsible for a significant amount of the chronic back pain. OA is considered a process of attempted, but gradually failing, repair of damaged cartilage extracellular matrix, as the balance between synthesis and breakdown of matrix components is disturbed and shifted towards catabolism. In recent times, members of the bone morphogenetic protein (BMP) family of proteins have demonstrated a great potential as anabolic factors for cartilage repair because of their ability to induce matrix synthesis and promote repair in cartilage.


Articular Cartilage Bone Morphogenetic Protein Cartilage Repair Degenerative Disc Disease Matrix Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Susan Chubinskaya
    • 1
  • Mark Hurtig
    • 2
  • David C. Rueger
    • 3
  1. 1.Department of BiochemistryRush University Medical CenterChicagoUSA
  2. 2.Guelph UniversityGuelphCanada
  3. 3.Stryker Biotech DivisionHopkintonUSA

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