The necessity for an interactive theory of immunity
It was known for a long time that certain immune reactions, particularly some that manifested themselves as skin swellings, were elicited by cells rather than soluble antibodies. For example, classical experiments of Chase in 1945 had shown that immunity of guinea pigs to tubercle bacilli, as tested by a skin reaction to tuberculin, was transferable to non-immune animals by lymph node cells but not by serum of immune animals1. This type of immunity had been termed “cellular immunity”, not knowing what it really was, to distinguish it from antibody-mediated “humoral immunity”. In his first paper on the transfer of transplantation immunity by lymph node cells in 1953 Mitchison commented “transplantation immunity shares with ... immunity to tuberculin the property of being transferred with greater facility by cells than by serum”2. In the absence of a paradigm that included immune mechanisms without antibodies, these observations were not followed by any sort of interpretation.
KeywordsTransplant Rejection Interactive Theory Foreign Antigen Mixed Lymphocyte Reaction Associative Recognition
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Chapter 7 References
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