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The Network Collective pp 62–71Cite as

The necessity for an interactive theory of immunity

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Abstract

It was known for a long time that certain immune reactions, particularly some that manifested themselves as skin swellings, were elicited by cells rather than soluble antibodies. For example, classical experiments of Chase in 1945 had shown that immunity of guinea pigs to tubercle bacilli, as tested by a skin reaction to tuberculin, was transferable to non-immune animals by lymph node cells but not by serum of immune animals1. This type of immunity had been termed “cellular immunity”, not knowing what it really was, to distinguish it from antibody-mediated “humoral immunity”. In his first paper on the transfer of transplantation immunity by lymph node cells in 1953 Mitchison commented “transplantation immunity shares with ... immunity to tuberculin the property of being transferred with greater facility by cells than by serum”2. In the absence of a paradigm that included immune mechanisms without antibodies, these observations were not followed by any sort of interpretation.

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Chapter 7 References

  1. Chase M (1945) The cellular transfer of cutaneous hypersensitivity to tuberculin. Proc Soc Exp Biol 59: 134

    Google Scholar 

  2. Mitchison NA (1953) Passive transfer of transplantation immunity. Nature 171: 267

    Article  PubMed  CAS  Google Scholar 

  3. Miller JFA (2003) Biological curiosities, what can we learn from them? In: Eichmann K (ed): The biology of complex organisms. Creation and protection of integrity. Birkhäuser, Basel

    Google Scholar 

  4. Miller JFA (1961) Immunological function of the thymus. Lancet 2: 748–749

    Article  PubMed  CAS  Google Scholar 

  5. Claman HN, Chaperon EA, Triplett RF (1966) Immunocompetence of transferred thymus-marrow cell combinations. J Immunol 97: 828–832

    PubMed  CAS  Google Scholar 

  6. Claman HN, Chaperon EA, Triplett RF (1966) Thymus-marrow cell combinations. Synergism in antibody production. Proc Soc Exp Biol Med 122: 1167–1171

    PubMed  CAS  Google Scholar 

  7. Miller JFA, Mitchell GF (1967) Thymus and precursors of antigen reactive cells. Nature 216: 659

    Article  PubMed  CAS  Google Scholar 

  8. Miller JFA, Mitchell GF (1968) Cell to cell interaction in immune response.1. Hemolysis-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes. J Exp Med 128: 801

    Article  PubMed  CAS  Google Scholar 

  9. Mitchell GF, Miller JFA (1968) Cell to cell interaction in immune response. 2. Source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes. J Exp Med 128: 821

    Article  PubMed  CAS  Google Scholar 

  10. Raff MC (1969) Theta isoantigen as a marker of thymus-derived lymphocytes in mice. Nature 224: 378–379

    Article  PubMed  CAS  Google Scholar 

  11. Moller G (1961) Demonstration of mouse isoantigens at cellular level by fluorescent antibody technique. J Exp Med 114: 415

    Article  Google Scholar 

  12. Raff MC (1970) Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence. Immunology 19: 637–650

    PubMed  CAS  Google Scholar 

  13. Raff MC, Sternberg M, Taylor RB (1970) Immunoglobulin determinants on the surface of mouse lymphoid cells. Nature 225: 553–554

    Article  PubMed  CAS  Google Scholar 

  14. Ford WL, Gowans J (1969) The traffic of lymphocytes. Semin Hematol 6: 67–83

    PubMed  CAS  Google Scholar 

  15. Cantor H, Boyse EA (1975) Development and function of subclasses of T cells. J Reticuloendothel Soc 17: 115–118

    PubMed  CAS  Google Scholar 

  16. Weissman IL, Masuda T, Olive C, Friedberg SH (1975) Differentiation of migration of T lymphocytes. Isr J Med Sci 11: 1267–1277

    PubMed  CAS  Google Scholar 

  17. Schlesinger M (1970) Anti-theta antibodies for detecting thymus-dependent lymphocytes in the immune response of mice to SRBC. Nature 226: 1254–1256

    Article  PubMed  CAS  Google Scholar 

  18. Playfair JH, Purves EC (1971) Antibody formation by bone marrow cells in irradiated mice. I. Thymus-dependent and thymus-independent responses to sheep erythrocytes. Immunology 21: 113–121

    PubMed  CAS  Google Scholar 

  19. Rajewsky K, Schirrmacher V, Nase S, Jerne NK (1969) The requirement of more than one antigenic determinant for immunogenicity. J Exp Med 129: 1131–1143

    Article  PubMed  CAS  Google Scholar 

  20. Mitchison NA (1971) The carrier effect in the secondary response to haptenprotein conjugates. II. Cellular cooperation. Eur J Immunol 1: 18–27

    Article  PubMed  CAS  Google Scholar 

  21. Ilya Ilyich Metchnikov: Intra-Cellular Digestion (1882), The Comparative Pathology of Inflammation (1892), and Immunity in Infectious Diseases (1905)

    Google Scholar 

  22. Zarafonetis C, Harmon DR, Clark PF (1947) The influence of temperature upon opsonization and phagocytosis. J Bacteriol 53: 343–349

    PubMed  CAS  Google Scholar 

  23. Mishell RI, Dutton RW (1967) Immunization of dissociated spleen cell cultures from normal mice. J Exp Med 126: 423–442

    Article  PubMed  CAS  Google Scholar 

  24. Askonas BA, Auzins I, Unanue ER (1968) Role of macrophages in the immune response. Bull Soc Chim Biol (Paris) 50: 1113–1128

    CAS  Google Scholar 

  25. Unanue ER, Cerottini JC (1970) The function of macrophages in the immune response. Semin Hematol 7: 225–248

    PubMed  CAS  Google Scholar 

  26. Bach FH, Voynow NK (1966) One-way stimulation in mixed leukocyte cultures. Science 153: 545–547

    Article  PubMed  CAS  Google Scholar 

  27. Wilson DB (1967) Quantitative studies on the mixed lymphocyte interaction in rats. I. Conditions and parameters of response. J Exp Med 126: 625–54

    Article  PubMed  CAS  Google Scholar 

  28. Simonsen M (1965) Recent experiments on the graft-versus-host reaction in the chick embryo. Br Med Bull 21: 129–32

    PubMed  CAS  Google Scholar 

  29. Nisbet NW, Simonsen M, Zaleski M (1969) The frequency of antigen-sensitive cells in tissue transplantation. A commentary on clonal selection. J Exp Med 129: 459–467

    Article  PubMed  CAS  Google Scholar 

  30. Klein J (1966) Strength of some H-2 antigens in mice. Folia Biol (Praha) 12: 168–175

    CAS  Google Scholar 

  31. Bach FH (1968) Transplantation: problems of histocompatibility testing. Science 159: 1196–1198

    Article  PubMed  CAS  Google Scholar 

  32. Bach FH, Amos DB (1967) Hu-1: Major histocompatibility locus in man. Science 156: 1506–1508

    Article  PubMed  CAS  Google Scholar 

  33. Davies DA, Manstone AJ, Viza DC, Colombani J, Dausset J (1968) Human transplantation antigens: the HL-A (Hu-1) system and its homology with the mouse H-2 system. Transplantation 6: 571–586

    Article  PubMed  CAS  Google Scholar 

  34. Ceppelini R (1971) Old and new facts and speculations about transplantation antigens of man. Progr Immunol I, Amos B. Ed. Academic Press, p. 973

    Google Scholar 

  35. Hayry P, Defendi V (1970) Mixed lymphocyte cultures produce effector cells: model in vitro for allograft rejection. Science 168: 133–135

    Article  PubMed  CAS  Google Scholar 

  36. Hayry P, Andersson LC (1973) T cells in mixed-lymphocyte-culture-induced cytolysis (MLC-CML). Transplant Proc 5: 1697–703

    PubMed  CAS  Google Scholar 

  37. Cerottini JC, Engers HD, Macdonald HR, Brunner T (1974) Generation of cytotoxic T lymphocytes in vitro. I. Response of normal and immune mouse spleen cells in mixed leukocyte cultures. J Exp Med 140: 703–717

    Article  PubMed  CAS  Google Scholar 

  38. Andersson LC, Hayry P (1973) Specific priming of mouse thymus-dependent lymphocytes to allogeneic cells in vitro. Eur J Immunol 3: 595–599

    Article  PubMed  CAS  Google Scholar 

  39. Andersson LC, Nordling S, Hayry P (1973) Allograft immunity in vitro. VI. Autonomy of T lymphocytes in target cell destruction. Scand J Immunol 2: 107–113

    Article  PubMed  CAS  Google Scholar 

  40. Gardner I, Bowern NA, Blanden RV (1974) Cell-mediated cytotoxicity against ectromelia virus-infected target cells. I. Specificity and kinetics. Eur J Immunol 4: 63–67

    Article  PubMed  CAS  Google Scholar 

  41. McDevitt HO, Sela M (1965) Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J Exp Med 122: 517–531

    Article  PubMed  CAS  Google Scholar 

  42. McDevitt HO, Sela M (1967) Genetic control of the antibody response II. Further analysis of the specificity of determinant-specific control, and genetic analysis of the response to (H,G)-A-L in CBA and C57 mice. J Exp Med 126: 969–978

    Article  PubMed  CAS  Google Scholar 

  43. Ellman L, Green I, Martin WJ, Benacerraf B (1970) Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs. Proc Natl Acad Sci USA 66: 322–328

    Article  PubMed  CAS  Google Scholar 

  44. Zinkernagel RM, Doherty PC (1974) Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248: 701–702

    Article  PubMed  CAS  Google Scholar 

  45. Zinkernagel RM (1974) Restriction by H-2 gene complex of transfer of cellmediated immunity to Listeria monocytogenes. Nature 251: 230–233

    Article  PubMed  CAS  Google Scholar 

  46. Kindred B (1975) The failure of allogeneic cells to maintain an immune response in nude mice. Scand J Immunol 4: 653–656

    Article  PubMed  CAS  Google Scholar 

  47. Katz DH, Graves M, Dorf ME, Dimuzio H, Benacerraf B (1975) Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex. J Exp Med 141: 263–268

    Article  PubMed  CAS  Google Scholar 

  48. Claman HN, McDonald W (1964) Thymus and X-irradiation in the termination of aquired immunological tolerance in the adult mouse. Nature 202: 713 Claman HN, Talmage DW (1963) Thymectomy: Prolongation of the immunological tolerance in the adult mouse. Science 141: 1193

    Article  Google Scholar 

  49. Droege W (1971) Amplifying and suppressive effect of thymus cells. Nature 234: 549–551

    Article  PubMed  CAS  Google Scholar 

  50. Gershon RK, Kondo K (1971) Infectious immunological tolerance. Immunology 21: 903–914 Gershon RK, Cohen P, Hencin R, Liebhaber SA. 1972. Suppressor T cells. J Immunol 108: 586–590

    PubMed  CAS  Google Scholar 

  51. Gershon RK (1975) A disquisition on suppressor T cells. Transplant Rev 26: 170–185

    PubMed  CAS  Google Scholar 

  52. Green DR, Flood PM, Gershon RK (1983) Immunoregulatory T cell pathways. Ann Rev Immunol 1: 439

    Article  CAS  Google Scholar 

  53. Jerne NK, (1971) The somatic generation of immune recognition. Eur J Immunol 1: 1

    Article  PubMed  CAS  Google Scholar 

  54. Bretscher P, Cohn M (1970) A theory of self-nonself discrimination. Science 169: 1042

    Article  PubMed  CAS  Google Scholar 

  55. Langman RE, Cohn M (1993) Two signal models of lymphocyte activation? Immunol Today 14: 235–237

    Article  PubMed  CAS  Google Scholar 

Further reading

  • Good RA, Finstad J (1968) The development and involution of the lymphoid system and immunologic capacity. Trans Am Clin Climatol Assoc 79: 69–107

    PubMed  CAS  Google Scholar 

  • Cohn M (1970) Selection under a somatic model. Cell Immunol 1: 461–467

    Article  PubMed  CAS  Google Scholar 

  • Cohn M (1972) Immunology: what are the rules of the game? Cell Immunol 5: 1–20

    Article  PubMed  CAS  Google Scholar 

  • Van Rood JJ, Van Leeuwen A, Freudenberg J, Rubinstein P (1971) Prospects in host-donor matching. Transplant Proc 3: 1042–50

    PubMed  Google Scholar 

  • Herzenberg LA, Chan EL, Ravitch MM, Riblet RJ, Herzenberg LA. (1973) Active suppression of immunoglobulin allotype synthesis. 3. Identification of T cells as responsible for suppression by cells from spleen, thymus, lymph node, and bone marrow. J Exp Med 137: 1311–1324

    Article  PubMed  CAS  Google Scholar 

  • Gershon RK, Mokyr MB, Mitchell MS (1974). Activation of suppressor T cells by tumour cells and specific antibody. Nature 250: 594–596

    Article  PubMed  CAS  Google Scholar 

  • Kirkwood JM, Gershon RK (1974) A role for suppressor T cells in immunological enhancement of tumor growth. Prog Exp Tumor Res 19: 157–164

    PubMed  CAS  Google Scholar 

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(2008). The necessity for an interactive theory of immunity. In: The Network Collective. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8373-2_7

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