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The enticing network: Fiction forever

Abstract

As discussed in chapter 7, in the early 1970s immunologists felt that a novel theory of adaptive immunity was badly needed. A first attempt was made in 1970 by Bretscher and Cohn, the “associative recognition” or “two-signal” hypothesis1. The citation rates indicate a growing attention until 1974 when Jerne launched his network theory2.Thereafter, Jerne’s citation rates rapidly rose to impressive levels, with an anti-parallel drop of that of the two-signal hypothesis to near insignificance. Only after the decline of the network paradigm, as of 1990, citation rates of the two-signal hypothesis recovered to intermediate levels which are maintained until recently (chapter 9, Fig. 9.4).

Keywords

Network Theory Citation Rate Network Concept Associative Recognition Internal Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Chapter 17 References

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Further reading

  1. Sercarz E, Oki A, Gammon G (1989) Central versus peripheral tolerance: Clonal inactivation versus suppressor T cells, the second half of the ‘thirty years war’. Immunol Suppl 2: 9PubMedGoogle Scholar

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© Birkhäuser Verlag AG 2008

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