As discussed in chapter 7, in the early 1970s immunologists felt that a novel theory of adaptive immunity was badly needed. A first attempt was made in 1970 by Bretscher and Cohn, the “associative recognition” or “two-signal” hypothesis1. The citation rates indicate a growing attention until 1974 when Jerne launched his network theory2.Thereafter, Jerne’s citation rates rapidly rose to impressive levels, with an anti-parallel drop of that of the two-signal hypothesis to near insignificance. Only after the decline of the network paradigm, as of 1990, citation rates of the two-signal hypothesis recovered to intermediate levels which are maintained until recently (chapter 9, Fig. 9.4).
KeywordsNetwork Theory Citation Rate Network Concept Associative Recognition Internal Image
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Chapter 17 References
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