This chapter contains a collection of interviews with immunologist colleagues who have, like myself, been involved in or exposed to the idiotypic network theory (INT) during a significant part of their active scientific career. Some of the key individuals in idiotype research have passed away, but those still living have been approached and many of them agreed to participate. In order to maintain a comparable structure, interviewees were sent a list of 15 questions well before the interview:
  1. Q1.

    What was your attitude to the INT in the beginning, say 1975–78?

  2. Q2.

    Have you been involved in idiotypic research prior to INT? If yes, what particular aspect?

  3. Q3.

    Did you get involved in idiotypic research as a result of INT? If yes, what particular aspect?

  4. Q4.

    Did you reject INT then? If yes, why?

  5. Q5.

    What are your views now about the former controversy about the Ig/non-Ig nature of the TCR?

  6. Q6.

    What do you think now about the former research on suppressor T cells?

  7. Q7.

    What about the inducer/transducer/effector concepts on helper/suppressor T cell circuits?

  8. Q8.

    What do you think about the former results on soluble helper and suppressor factors?

  9. Q9.

    Do you think INT had a stimulating/inhibitory influence in immunological research?

  10. Q10.

    Do you think that some of the research on INT was useful or a waste of time?

  11. Q11.

    Do you think that there was a difference in acceptance of INT in Europe vs. US?

  12. Q12.

    Why do you think the INT disappeared from mainstream immunology?

  13. Q13.

    What do you think now, do you think the INT was correct, wrong, or to some extent correct?

  14. Q14.

    What were the paradigms in immunology that superseded INT?

  15. Q15.

    There are still attempts at idiotypic approaches in clinical research, i.e. autoimmunity, cancer, vaccines.What are your views?



Network Theory Suppressor Cell Cell Repertoire Internal Image Suppressor Factor 


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