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Histology and immunohistology of myocarditis

  • Annalisa Angelini
  • Fiorella Calabrese
  • Gaetano Thiene
Part of the Progress in Inflammation Research book series (PIR)

Abstract

The contemporary definition and classification of cardiomyopathies by the American Heart Association recently listed myocarditis (inflammatory cardiomyopathy) among the primary cardiomyopathies (predominantly involving the heart) as opposed to the secondary forms (mainly involving the heart in the setting of generalized systemic disease). Endomyocardial biopsy (EMB) is still considered the gold standard for the in vivo diagnosis of myocarditis, its sensibility and specificity being increased by the application of immunohistochemistry and morphometric analysis. Obtaining tissue samples from multiple areas of the ventricles greatly increases the sensibility of EMB in detecting myocarditis since the process could be focal, regional or diffuse. Dallas criteria, recognizing inflammatory infiltrates with necrosis and/or degeneration of the adjacent myocytes (not typical of the ischemic damage associated with coronary artery disease)as the key for diagnosis, should be complemented by the introduction of new criteria that should include: clinical presentation, histopathology, immunohistochemistry, morphometry, viral polymerase chain reaction, cardiac antibodies assessment, and imaging findings.

Keywords

Dilate Cardiomyopathy Endomyocardial Biopsy Idiopathic Dilate Cardiomyopathy Inflammatory Cell Infiltrate Viral Myocarditis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel 2010

Authors and Affiliations

  • Annalisa Angelini
    • 1
  • Fiorella Calabrese
    • 1
  • Gaetano Thiene
    • 1
  1. 1.Department of Medico-diagnostic Sciences and Special Therapies, Special Pathological AnatomyUniversity of Padua Medical SchoolPadovaItaly

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