Clinical management of acute myocarditis and cardiomyopathy

  • Kenneth L. Baughman
Part of the Progress in Inflammation Research book series (PIR)


Several forms of acute myocarditis may present as new onset cardiomyopathy and congestive heart failure. These include myocarditis characterized as fulminant, giant cell, chronic acute, eosinophilic (particularly necrotizing eosinophilic myocarditis), peripartum, Lyme, small pox vaccine related, HIV-related, and acute myocardial infarction caused by myocarditis with coronary arteritis. Treatment of each of these disorders is dependent upon considering the diagnosis, performing endomyocardial biopsy for histologic confirmation, and use of immune modulating or immunosuppressive therapy in appropriate candidates. Some forms of acute myocarditis may resolve spontaneously without any treatment including fulminant myocarditis, peripartum, and small pox vaccine related myocarditis. Others require immune modulating therapy including giant cell myocarditis, and eosinophilic myocarditis; while others require specific treatment for the infectious or autoimmune pathogen responsible including eosinophilic myocarditis, Lyme myocarditis, and HIV-related. We currently have the technology which may allow us to determine if the 50% of patients with “idiopathic” cardiomyopathy in fact have a viral or post viral autoimmune related compromise of cardiac function.


Dilate Cardiomyopathy Cardiac Sarcoidosis Acute Myocarditis Peripartum Cardiomyopathy Smallpox Vaccination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Basel 2010

Authors and Affiliations

  • Kenneth L. Baughman
    • 1
  1. 1.Advanced Heart Disease Section, Division of Cardiovascular MedicineBrigham and Women’s HospitalBostonUSA

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