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Molecular, Clinical and Environmental Toxicology pp 317–338Cite as

Analytical toxicology

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Part of the book series: Experientia Supplementum ((EXS,volume 100))

Abstract

This paper reviews procedures for screening, identification and quantification of drugs, poisons and their metabolites in biosamples, and the corresponding work-up procedures. Gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry are mostly used today in analytical toxicology. Selection of the most appropriate biosample, e.g., ante/postmortem blood, urine, or tissues or alternative matrices like hair, sweat and oral fluid, nails or meconium, is discussed. The importance of quality control and possibilities and limitations of interpretation of the analytical result are also discussed.

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Authors and Affiliations

  1. Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University Hospital, Building 46, 66421, Homburg (Saar), Germany

    Hans H. Maurer

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  1. Federal Institute for Risk Assessment, Thielallee 88-92, 14195, Berlin, Germany

    Andreas Luch

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Maurer, H.H. (2010). Analytical toxicology. In: Luch, A. (eds) Molecular, Clinical and Environmental Toxicology. Experientia Supplementum, vol 100. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8338-1_9

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