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Toxicogenomics: transcription profiling for toxicology assessment

  • Tong Zhou
  • Jeff Chou
  • Paul B. Watkins
  • William K. Kaufmann
Part of the Experientia Supplementum book series (EXS, volume 99)

Abstract

Toxicogenomics, the application of transcription profiling to toxicology, has been widely used for elucidating the molecular and cellular actions of chemicals and other environmental stressors on biological systems, predicting toxicity before any functional damages, and classification of known or new toxicants based on signatures of gene expression. The success of a toxicogenomics study depends upon close collaboration among experts in different fields, including a toxicologist or biologist, a bioinformatician, statistician, physician and, sometimes, mathematician. This review is focused on toxicogenomics studies, including transcription profiling technology, experimental design, significant gene extraction, toxicological results interpretation, potential pathway identification, database input and the applications of toxicogenomics in various fields of toxicological study.

Keywords

Gene Expression Profile Acute Lung Injury Diesel Exhaust Particle Transcription Profile Toxicology Assessment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag/Switzerland 2009

Authors and Affiliations

  • Tong Zhou
    • 1
  • Jeff Chou
    • 2
  • Paul B. Watkins
    • 1
  • William K. Kaufmann
    • 3
  1. 1.Center for Drug Safety Sciences, The Hamner Institutes for Health SciencesUniversity of North Carolina at Chapel HillResearch Triangle ParkUSA
  2. 2.Microarray Group, National Institute for Environmental Health Sciences (NIEHS)Research Triangle ParkUSA
  3. 3.Department of Pathology and Laboratory Medicine, Center for Environmental Health andSusceptibilityUniversity of North Carolina at Chapel HillChapel HillUSA

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