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Toxicogenomics: transcription profiling for toxicology assessment

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Molecular, Clinical and Environmental Toxicology

Part of the book series: Experientia Supplementum ((EXS,volume 99))

Abstract

Toxicogenomics, the application of transcription profiling to toxicology, has been widely used for elucidating the molecular and cellular actions of chemicals and other environmental stressors on biological systems, predicting toxicity before any functional damages, and classification of known or new toxicants based on signatures of gene expression. The success of a toxicogenomics study depends upon close collaboration among experts in different fields, including a toxicologist or biologist, a bioinformatician, statistician, physician and, sometimes, mathematician. This review is focused on toxicogenomics studies, including transcription profiling technology, experimental design, significant gene extraction, toxicological results interpretation, potential pathway identification, database input and the applications of toxicogenomics in various fields of toxicological study.

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Authors and Affiliations

  1. Center for Drug Safety Sciences, The Hamner Institutes for Health Sciences, University of North Carolina at Chapel Hill, Research Triangle Park, NC, USA

    Tong Zhou & Paul B. Watkins

  2. Microarray Group, National Institute for Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA

    Jeff Chou

  3. Department of Pathology and Laboratory Medicine, Center for Environmental Health andSusceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    William K. Kaufmann

Authors
  1. Tong Zhou
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  2. Jeff Chou
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  3. Paul B. Watkins
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  4. William K. Kaufmann
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Editor information

Editors and Affiliations

  1. Federal Institute for Risk Assessment, Thielallee 88-92, 14195, Berlin, Germany

    Andreas Luch

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© 2009 Birkhäuser Verlag/Switzerland

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Zhou, T., Chou, J., Watkins, P.B., Kaufmann, W.K. (2009). Toxicogenomics: transcription profiling for toxicology assessment. In: Luch, A. (eds) Molecular, Clinical and Environmental Toxicology. Experientia Supplementum, vol 99. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8336-7_12

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