Mapping the epigenome — impact for toxicology

  • Jennifer Marlowe
  • Soon-Siong Teo
  • Salah-Dine Chibout
  • François Pognan
  • Jonathan Moggs
Part of the Experientia Supplementum book series (EXS, volume 99)


Recent advances in technological approaches for mapping and characterizing the epigenome are generating a wealth of new opportunities for exploring the relationship between epigenetic modifications, human disease and the therapeutic potential of pharmaceutical drugs. While the best examples for xenobiotic-induced epigenetic perturbations come from the field of non-genotoxic carcinogenesis, there is growing evidence for the relevance of epigenetic mechanisms associated with a wide range of disease areas and drug targets. The application of epigenomic profiling technologies to drug safety sciences has great potential for providing novel insights into the molecular basis of long-lasting cellular perturbations including increased susceptibility to disease and/or toxicity, memory of prior immune stimulation and/or drug exposure, and transgenerational effects.


Circulate Tumor Cell B6C3F1 Mouse Restriction Landmark Genomic Scan Epigenomic Profile Human Epigenome Project 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag/Switzerland 2009

Authors and Affiliations

  • Jennifer Marlowe
    • 1
  • Soon-Siong Teo
    • 1
  • Salah-Dine Chibout
    • 1
  • François Pognan
    • 1
  • Jonathan Moggs
    • 1
  1. 1.Novartis Pharma AGInvestigative Toxicology, Preclinical SafetyBaselSwitzerland

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