E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?

  • Irene Puga
  • Fernando Macian
Part of the Progress in Inflammation Research book series (PIR)


The success of adaptive immunity relies on the ability to eliminate invading pathogens without eliciting responses against the host. Unique antigen receptors are randomly generated and recognize both self and non-self antigens. Therefore, mechanisms of tolerance must be in place to control the activity of self-reactive lymphocytes. Negative selection in the thymus eliminates most of the developing thymocytes that can recognize self antigens 1, whereas mechanisms of peripheral tolerance prevent the surviving self-reactive cells from engaging in responses against self tissues. Self-reactive T cells can be suppressed by regulatory T cells, and also eliminated by clonal deletion or inactivated by a mechanism known as anergy 2. In anergic T cells, T cell receptor (TCR) signaling is blocked, and cells become unresponsive to subsequent stimulation events 3, 4, 5.


Cell Tolerance Cell Anergy Immune Synapse Anergy Induction Supramolecular Activation Cluster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Irene Puga
    • 1
  • Fernando Macian
    • 1
  1. 1.Department of PathologyAlbert Einstein College of MedicineBronxUSA

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