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The Immune Synapse as a Novel Target for Therapy pp 71–86Cite as

Immune modulation by CD40L blockade

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

CD40L (CD154), a member of TNF-TNFR superfamily, binds to CD40 and several integrins, and plays the key role in host immune responses [1]. Blockade of the CD40-CD40L costimulation pathway has proven to be highly effective in modulating various types of immune responses, including anti-microbial, autoimmune, alloimmune responses, allergy, as well as tissue inflammation of both antigen-specific and nonspecific types. In particular, CD154 blockade has been widely applied in organ transplant models, from rodents to primates [2]. In this review, we focus on recent literature with emphasis on in vivo immunological mechanisms.

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  1. The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA

    Yuan Zhai & Jerzy W. Kupiec-Weglinski

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  1. Yuan Zhai
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  2. Jerzy W. Kupiec-Weglinski
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  1. Unidade de Imunologia Celular Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz, 1649-208, Lisboa, Portugal

    Luis Graca

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© 2008 Birkhäuser Verlag Basel/Switzerland

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Zhai, Y., Kupiec-Weglinski, J.W. (2008). Immune modulation by CD40L blockade. In: Graca, L. (eds) The Immune Synapse as a Novel Target for Therapy. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8296-4_6

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