Targeting CD4 for the induction of dominant tolerance

  • Herman Waldmann
  • Elizabeth Adams
  • Stephen Cobbold
Part of the Progress in Inflammation Research book series (PIR)


It was long known from the work of Chiller and Weigle, in the 1970s [1], that deaggregated (monomeric) foreign immunoglobulins were poorly immunogenic, and capable of inducing tolerance. Aggregated immunoglobulins were, in contrast, very immunogenic.


Donor Chimerism Transplantation Tolerance Donor Antigen Infectious Tolerance Indirect Presentation 
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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Herman Waldmann
    • 1
  • Elizabeth Adams
    • 1
  • Stephen Cobbold
    • 1
  1. 1.Sir William Dunn School of PathologyOxford UniversityOxfordUK

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