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Targeting CD4 for the induction of dominant tolerance

  • Chapter
The Immune Synapse as a Novel Target for Therapy

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

It was long known from the work of Chiller and Weigle, in the 1970s [1], that deaggregated (monomeric) foreign immunoglobulins were poorly immunogenic, and capable of inducing tolerance. Aggregated immunoglobulins were, in contrast, very immunogenic.

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Author information

Authors and Affiliations

  1. Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford, OX1 3RE, UK

    Herman Waldmann, Elizabeth Adams & Stephen Cobbold

Authors
  1. Herman Waldmann
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  2. Elizabeth Adams
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  3. Stephen Cobbold
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Editor information

Editors and Affiliations

  1. Unidade de Imunologia Celular Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz, 1649-208, Lisboa, Portugal

    Luis Graca

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© 2008 Birkhäuser Verlag Basel/Switzerland

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Waldmann, H., Adams, E., Cobbold, S. (2008). Targeting CD4 for the induction of dominant tolerance. In: Graca, L. (eds) The Immune Synapse as a Novel Target for Therapy. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8296-4_4

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