The induction of regulatory T cells by targeting the immune synapse

  • Luis Graca
Part of the Progress in Inflammation Research book series (PIR)


The control of deleterious immune responses causing diseases, such as allergy, autoimmunity and transplant rejection, has been one of the main objectives of immunologists. In recent years, regulatory T (Treg) cells have reached center-stage in immunology research, as they were shown to be effective in preventing deleterious immune responses and maintaining a healthy state of immunological non-responsiveness, also known as immune tolerance [1]. It is now accepted that a natural population of Treg cells is generated in the thymus and plays a major role in preventing autoimmunity [2]. Several research groups have been developing strategies to isolate and expand rare self-reactive Treg cell clones as a therapeutic strategy for autoimmunity [3, 4].


Treg Cell Nonobese Diabetic Mouse Transplantation Tolerance Altered Peptide Ligand Immune Synapse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2008

Authors and Affiliations

  • Luis Graca
    • 1
    • 2
  1. 1.Instituto de Medicina Molecular, Faculdade de MedicinaUniversidade de LisboaLisboa
  2. 2.Instituto Gulbenkian de CiênciaOeirasPortugal

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