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Signaling pathways in rheumatoid arthritis

  • Chapter
New Therapeutic Targets in Rheumatoid Arthritis

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Signaling pathways orchestrate the inflammatory response by regulating various cellular functions such as programmed cell death, cell differentiation and proliferation or secretion of signaling molecules. They are classically activated by ligand engagement of surface receptors but increasing evidence suggests that intracellular proteins can also detect danger signals. Protection from pathogens, chemical or physical injury, or neoplasia relies on a tightly regulated activation of these mechanisms. The same signaling cascades sometimes escape from normal controls and increase the production of cytokines, proteases, growth factors and chemokines up to harmful levels, leading to an autodestructive process as seen in rheumatoid arthritis. Mapping the hierarchy of these pathways identifies which specific targets can be inhibited to safely reduce the levels of inflammatory molecules and reset the homeostasis of the organism.

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Authors and Affiliations

  1. Department of Medicine, University of California, San Diego, La Jolla, CA, 92093-0656, USA

    Jean-Marc Waldburger & Gary S. Firestein

  2. Centre médical universitaire, University of Geneva, 1 rue Michel Servet, 1211, Geneva, Switzerland

    Jean-Marc Waldburger

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  1. Jean-Marc Waldburger
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  2. Gary S. Firestein
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Editors and Affiliations

  1. Division of Clinical Immunology and Rheumatology EULAR & FOCIS Center of Excellence Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room F4-218, 1105, AZ Amsterdam, The Netherlands

    Paul-Peter Tak

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Waldburger, JM., Firestein, G.S. (2009). Signaling pathways in rheumatoid arthritis. In: Tak, PP. (eds) New Therapeutic Targets in Rheumatoid Arthritis. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8238-4_9

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