IL-17 and Th17 cells, key players in arthritis
IL-17 was identified in 1995/96 as a T cell-derived cytokine with effects on inflammation and neutrophil activation. Rheumatoid arthritis (RA) has emerged as the best-studied situation to justify the selection of IL-17 as a therapeutic target. By interacting with other proinflammatory cytokines, IL-17 was found to induce bone and cartilage destruction. In 2006, the precise cell source of IL-17 was identified in the mouse. These cells were named Th17, and a key role for these cells was demonstrated in various situations associated with inflammation. These new findings confirmed and extended the results previously obtained following the identification of IL-17 as a T cell-derived cytokine. At the same time, additional information was obtained on the other members of the IL-17 family and on the structure of the IL-17 receptor complex. Such knowledge has further extended the choice of possible modalities to control IL-17.
KeywordsTh17 Cell Rheumatoid Arthritis Synovium Collagen Arthritis Tumor Necrosis Factor Alpha Block Necrosis Factor Alpha Block
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