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Targeting oncostatin M in the treatment of rheumatoid arthritis

  • Theresa C. Barnes
  • Robert J. Moots
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Oncostatin M (OSM) is a pleiotropic cytokine with potential utility as a treatment for inflammatory arthritis. This pro-inflammatory cytokine is increased in the rheumatoid but not in the osteoarthritic joint. Strategies to block the actions of OSM for use in inflammatory arthritis are being developed and these show significant promise in murine models of disease. Targeting OSM may have a beneficial effect by inhibiting some of the mechanisms of joint destruction in rheumatoid arthritis, which may limit long-term disability in patients. The challenge now is to convert this potential into firm compounds that can be tested in the clinic.

Keywords

Rheumatoid Arthritis Synovial Fluid Leukaemia Inhibitory Factor Inflammatory Arthritis Adenoviral Gene Transfer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2009

Authors and Affiliations

  • Theresa C. Barnes
    • 1
  • Robert J. Moots
    • 1
  1. 1.Division of Inflammation, School of Clinical SciencesUniversity of Liverpool, University Hospital AintreeLiverpoolUK

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