Cell-based Models of Blood Clotting
The formation of platelet aggregates during blood clotting is modeled on two scales. The microscopic scale models track individual platelets, their mechanical interactions with one another and the surrounding fluid, their detection of and response to chemical activators, and the formation of cohesive and adhesive ‘links’ between platelets and between platelets and the vascular wall. These models allow inclusion of detailed mechanisms of binding-unbinding, platelet stimulus-response, and chemistry on the platelets’ surfaces. The macroscopic scale models treat the same interactions in terms of concentrations of platelets and distributions of cohesive and adhesive links, and can be used to study platelet aggregation in vessels of clinical interest including the coronary and cerebral arteries.
KeywordsPlatelet Aggregation Cerebral Artery Scale Model Vascular Wall Macroscopic Scale
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