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Cell-based Models of Blood Clotting

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Single-Cell-Based Models in Biology and Medicine

Part of the book series: Mathematics and Biosciences in Interaction ((MBI))

Abstract

The formation of platelet aggregates during blood clotting is modeled on two scales. The microscopic scale models track individual platelets, their mechanical interactions with one another and the surrounding fluid, their detection of and response to chemical activators, and the formation of cohesive and adhesive ‘links’ between platelets and between platelets and the vascular wall. These models allow inclusion of detailed mechanisms of binding-unbinding, platelet stimulus-response, and chemistry on the platelets’ surfaces. The macroscopic scale models treat the same interactions in terms of concentrations of platelets and distributions of cohesive and adhesive links, and can be used to study platelet aggregation in vessels of clinical interest including the coronary and cerebral arteries.

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Author information

Authors and Affiliations

  1. Departments of Mathematics and Bioengineering, University of Utah, 155 South 1400 East, 233 JWB, Salt Lake City, Utah, 84112

    Aaron L. Fogelson

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  1. Aaron L. Fogelson
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Editor information

Editors and Affiliations

  1. Division of Mathematics, University of Dundee, 23 Perth Road, Dundee, DD1 4HN, UK

    Alexander R. A. Anderson , Mark A. J. Chaplain  & Katarzyna A. Rejniak ,  & 

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© 2007 Birkhäuser Verlag Basel/Switzerland

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Fogelson, A.L. (2007). Cell-based Models of Blood Clotting. In: Anderson, A.R.A., Chaplain, M.A.J., Rejniak, K.A. (eds) Single-Cell-Based Models in Biology and Medicine. Mathematics and Biosciences in Interaction. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8123-3_11

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