Abstract
This chapter describes a new method for simulating grid-free multicellular structures, in which the three-dimensional shape of each cell is dynamically adaptive to its local environment. This is achieved by constructing each cell from “subcellular elements.” I describe in detail the underlying mathematical equation of motion for the elements, and the additional algorithms which allow for cell growth and cell division. The model is illustrated with the simple example of a growing three dimensional cluster of cells.
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References
J. A. Glazier and F. Graner, Simulation of the Differential Adhesion Driven Rearrangement of Biological Cells Phys. Rev. E 47 (1993), 2128–2154.
E. Palsson and H. G. Othmer, A Model for Individual and Collective Cell Movement in Dictyostelium discoideum Proc. Natl. Acad. Sci. (USA) 97 (2000), 10448–10453.
D. Drasdo, R. Kree, and J. S. McCaskill, Monte Carlo Approach to Tissue-Cell Populations Phys. Rev. E 52 (1995), 6635–6657.
K. A. Rejniak, A Single Cell Approach in Modeling the Dynamics of Tumor Microregions Math. Biosci. Eng. 2 (2005), 643–655.
T. J. Newman, Modeling Multicellular Systems Using Subcellular Elements Math. Biosci. Eng. 2 (2005), 611–622.
B. Alberts et al, Molecular Biology of the Cell 4th Edition, Garland, New York 2002.
R. E. Keller and M. Danilchik, Regional Expression, Pattern and Timing of Convergence and Extension During Gastrulation of Xenopus laevis Development 103, 193–209.
L. A. Davidson, M. A. R. Koehl, R. Keller, and G. F. Oster, How Do Sea Urchins Invaginate — Using Biomechanics to Distinguish Between Mechanisms of Primary Invagination Development 121 (1995), 2005–2018.
M. E. Gracheva and H. G. Othmer, A Continuum Model of Motility in Amoeboid Cells Bull. Math. Biol. 66 (2004), 167–193.
R. Grima, Ph.D. Thesis Arizona State University (2005).
D. C. Rapaport, The Art of Molecular Dynamics Simulation Cambridge University Press 2004.
N. G. van Kampen, Stochastic Processes in Physics and Chemistry North Holland, Amsterdam 1992.
S. Sandersius and T. J. Newman, in preparation.
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© 2007 Birkhäuser Verlag Basel/Switzerland
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Newman, T.J. (2007). Modeling Multicellular Structures Using the Subcellular Element Model. In: Anderson, A.R.A., Chaplain, M.A.J., Rejniak, K.A. (eds) Single-Cell-Based Models in Biology and Medicine. Mathematics and Biosciences in Interaction. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8123-3_10
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DOI: https://doi.org/10.1007/978-3-7643-8123-3_10
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-7643-8101-1
Online ISBN: 978-3-7643-8123-3
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