Abstract
Kawasaki disease was first reported in Japan in 1967 by Dr. Tomisaku Kawasaki. It has since been recognized worldwide, and in at the United States and Japan is the most important cause of acquired heart disease in children, surpassing other more recognized conditions such as rheumatic fever, endocarditis and myocarditis. It is primarily a disease of children less than 5 years of age but has been reported in older children and adults. Risk factors for the illness include Asian ancestry, male gender and certain familial predispositions. Observations such as similarity to certain exanthematous infectious diseases, temporal-geographic clustering of cases and seasonality in incidence favors an infectious etiology. Pathology and pathogenesis of the disease indicate that it is a medium-sized artery vasculitis that results from a dramatic immune activation that in most cases reversed by immune modulating agents such as intravenous immunoglobulin. Unfortunately, the etiology of the illness remains obscure, although recent studies favor a possible viral etiology.
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Keywords
- Vascular Endothelial Growth Factor
- Kawasaki Disease
- Pediatr Infect
- Toxic Shock Syndrome
- Coronary Artery Lesion
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Kawasaki T (1967) Pediatric acute mucocutaneous lymph node syndrome: clinical observations of 50 cases. Arerugi (Jpn J Allergy) 16: 178–222
Burus JC, Kushner HI, Bastian JF, Shike M, Shimizu C, Matsubara T, Turner C (2000) Kawasaki disease; a brief history. Pediatrics 106: e27
Melish ME, Hicks RM, Larson E (1974) Mucocutaneous lymph node syndrome in the United States. Pediatr Res 8: 427A
Landing BH, Larson EJ (1976) Are infantile periarteritis nodosa and fatal mucocutaneous lymph node syndrome the same? Pediatrics 59: 651–662
Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, Shulman ST, Bolger AF, Ferrieri P, Baltimore RS et al (2004) AHA Scientific Statement. Diagnosis, treatment and long-term management of Kawasaki disease. A statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young American Heart Association. Circulation 110: 2747–2771
Yanagawa H, Nakamura Y, Yashiro M, Uehara R, Oki I, Kayaba K (2006) Incidence of Kawasaki disease in Japan: The nationwide surveys of 1999–2002. Pediatr Int 48: 356–361
Yanagawa H, Yashiro H, Nakamura Y, Kawasaki T, Koto H (1995) The results of 12 nationwide epidemiological incidence surveys of Kawasaki disease in Japan. Arch Pediatr Adolesc Med 149: 779–783
Yanagawa H, Yashiro M, Nakamura Y, Kawasaki T, Koto H (1995) Epidemiologic pictures of Kawasaki disease in Japan from the nationwide incidence survey in 1991–1992. Pediatrics 95: 475–479
Yanagawa H, Nakamura Y, Yashiro M, Ojima T, Tinahara S, Oki I, Zhang T (1998) Results of the nationwide epidemiologic survey of Kawasaki disease in 1995 and 1996 in Japan. Pediatrics 102: e65
Yanagawa H, Nakamura Y, Yashiro M, Oki I, Hirata S. Zhang T, Kawasaki T (2001) Incidence survey of Kawasaki disease in 1997 and 1998 in Japan. Pediatrics 107: e33
Yanagawa H, Nakamura Y, Ojima T, Yashiro M, Tanihara S, Oki I (1999) Changes in epidemic patterns of Kawasaki disease in Japan. Pediatr Infect Dis J 18: 64–66
Dean AG, Melish ME, Hicks R, Palumbo E (1982) An epidemic of Kawasaki disease in Hawaii. J Pediatr 100: 552–557
Shulman ST, McAuley JB, Pachman LM, Miller ML, Ruschhaupt DG (1987) Risk of coronary artery abnormalities due to Kawasaki disease in an urban area with small Asian population. Am J Dis Child 141: 420–425
Mason WH, Kodama D, Takahashi M (2002) The epidemiology of Kawasaki in a large urban center over a 21 year period. Pediatric Academic Societies Annual Meeting, May 17–22, 2002. Abstract # 283
Holman RC, Curns AT, Belay ED, Steiner CA, Schonberger LB (2003) Kawasaki syndrome hospitalizations in the United States, 1997 and 2000. Pediatrics 112: 495–501
Taubert KA (1997) Epidemiology of Kawasaki disease in the United States and worldwide. Prog Pediatr Cardiol 6: 181–185
Steiner C, Elixhauser A, Schnaier J (2002) The healthcare cost and utilization project: an overview. Eff Clin Pract 5: 143–151
Chang RKR (2002) Epidemiologic characteristics of children hospitalized for Kawasaki disease in California. Pediatr Infect Dis J 21: 1150–1155
Gibbons RV, Parashar VD, Holman RC, Belay ED, Maddox RA, Powell KE, Schonberger LB (2002) An evaluation of hospitalizations for Kawasaki syndrome in Georgia. Arch Pediatr Adolesc Med 156: 492–496
Belay ED, Holman RC, Clark MJ, Destefano F, Shahriari A, Davis RL, Rhodes PH, Thompson RS, Block SB, Shinefield HR et al (2000) The incidence of Kawasaki syndrome in West Coast health maintenance organizations. Pediatr Infect Dis J 19: 828–832
Centers for Disease Control (1985) Multiple outbreaks of Kawasaki syndrome — United States. JAMA 253: 957–958
Han RK, Sinclair B, Newman A, Silverman ED, Taylor GW, Walsh P, McCrindle BW (2000) Recognition and management of Kawasaki disease. CMAJ 162: 807–812
Du Z-D, Zhang T, Liang L, Meng X, Li T, Kawasaki T, Nakamura Y, Yanagawa H (2002) Epidemiologic picture of Kawasaki disease in Beijing from 1995 through 1999. Pediatr Infect Dis J 21: 103–107
Ng YM, Sung RY, Fong NC, Ho MH, Cheng YW, Lee SH, Wok WC, Wong DM, Yan MC, Kwok KL, Chin WK (2005) Kawasaki Disease in Hong Kong 1994–2000. Hong Kong Med J 11: 331–335
Huang GY, Ma XJ, Huang M, Huang MR, Gui YH, Ning SB, Zhang TH, Du ZD, Yanagawa H, Kawasaki T (2006) Epidemiologic pictures of Kawasaki disease in Shanghai from 1998 through 2002. J Epidemiol 16: 9–14
Chang LY, Chang IS, Lu CY, Chiang BL, Lee CY, Chen PJ, Wang JT, Ho HN, Chen DS, Huang LM et al (2004) Epidemiologic features of Kawasaki disease in Taiwan, 1996–2002. Pediatrics 114: 678–682
Park YW, Han JW, Park IS, Kim CH, Yun YS, Cha SH, Ma JS, Lee SB, Chul HK, Lee HJ, Tockgo YC (2005) Epidemiologic picture of Kawasaki disease in Korea 2000–2002. Pediatr Int 47: 382–387
Lynch M, Holman RC, Mulligan A, Belay ED, Schonberger LB (2003) Kawasaki syndrome hospitalizations in Ireland, 1996 through 2000. Pediatr Infect Dis J 22: 959–962
Salo E, Pelkonen P, Pettay O (1986) Outbreak of Kawasaki syndrome in Finland. Acta Paediatr Scand 75: 75–80
Holman RC, Curns AT, Belay ED, Steiner CA, Effler PV, Yarita KL, Miyamura J, Forbes S, Schonberger B (2005) Kawasaki syndrome in Hawaii. Pediatr Infect Dis J 24: 429–433
Holman RC, Belay ED, Clark MJ, Kaufman SF, Schonberger LB (1999) Kawasaki syndrome among American Indian and Alaskan native children, 1980 through 1995. Pediatr Infect Dis J 18: 451–455
Bell DM, Brink EW, Nitzkin JL, Hall CB, Wulff H, Berkowitz ID, Feorino PM, Holman RC, Hautley CL, Meade RH et al (1981) Kawasaki syndrome: description of two outbreaks in the United States. N Engl J Med 304: 1568–1575
Belay ED, Maddox RA, Holman RC, Curns AT, Ballah K, Schonberger LB (2006) Kawasaki syndrome and risk factors for coronary artery abnormalities. Pediatr Infect Dis J 25: 245–249
Stockheim JA, Innocentini N, Shulman ST (2000) Kawasaki disease in older children and adolescents. J Pediatr 137: 250–252
Pannaraj PS, Turner CL, Bastian JF, Burns JC (2004) Failure to diagnose Kawasaki disease at the extremes of the pediatric age. Pediatr Infect Dis J 23: 789–791
Lee KY, Hong JH, Han JW, Lee JS, Lee BC, Burgner D (2006) Features of Kawasaki disease at the extremes of age. J Pediatr Child Health 42: 423–427
Seve P, Stankovic K, Smail A, Durand DY, Marchand G, Broussolle C (2005) Adult Kawasaki disease: report of two cases and literature review. Semin Arthritis Rheum 34: 785–792
Rauch AM (1987) Kawasaki syndrome review of new epidemiologic and laboratory developments. Pediatr Infect Dis J 6: 1016–1021
Bronstein DE, Dille AN, Austin JP, Williams CM, Palinkas LA, Burns JC (2000) Relationship of climate, ethnicity and socioeconomic class to Kawasaki disease in San Diego County, 1994 through 1998. Pediatr Infect Dis J 19: 1087–1091
Burns JC, Cayan DR, Tong G, Bainto EY, Turner CL, Shike T, Nakamura Y, Yashiro M, Yanagawa H (2005) Seasonality and temporal clustering of Kawasaki syndrome. Epidemiology 16: 220–225
Mason WH, Schneider T, Takahashi M (1991) The epidemiology and etiology of Kawasaki disease. Cardiol Young 1: 196–205
Hirata S, Nakamura Y, Yanagawa H (2001) Incidence rate of recurrent Kawasaki disease and related risk factors from the results of nationwide surveys of Kawasaki disease in Japan. Acta Pediatr 90: 40–44
Fujita Y, Nakamura Y, Sakata K, Hara N, Kobayashi M, Yanagawa H, Kawasaki T (1989) Kawasaki disease in families. Pediatrics 84: 666–669
Uehara R, Yashuro M, Nakamur Y, Yanagawa H (2004) Clinical features of patients with Kawasaki disease whose parents had the same disease. Arch Pediatr Adolesc Med 1166–1169
Dergun M, Kao A, Hauger SB, Newburger JW, Burns JC (2005) Familial occurrence of Kawasaki syndrome in North America. Arch Pediatr Adolesc Med 159: 876–881
Mason WH, Takahashi T, Schneider T (1991) Recurrence of Kawasaki disease in a large urban cohort in the United States. In: M Takahashi, K Taubert (eds): Proceedings of the 4th International Symposium on Kawasaki Disease. American Heart Association, Dallas, Texas, 21–26
Morens DM, Anderson LJ, Hurwitz ES (1980) National Surveillance of Kawasaki disease. Pediatrics 65: 21–25
Belay ED, Holman RC, Maddox RA, Foster DA, Schonberger LB (2003) Kawasaki syndrome hospitalizations and associated costs in the United States. Public Health Rep 118: 464–469
Treadwell TA, Maddox RA, Holman RC, Belay ED, Shahirari A, Anderson MS, Burns J, Glode MP, Hoffman RE, Schonberger LB (2002) Investigation of Kawasaki syndrome risk factors in Colorado. Pediatr Infect Dis J 21: 976–978
Mason WH, Takahashi M (1999) Kawasaki syndrome. Clin Infect Dis 28: 169–187
Brosuis CL, Newburger JW, Burus JC, Hojnowski-Diaz P, Zierler S, Leung DY (1988) Increased prevalence of atopic dermatitis in Kawasaki disease. Pediatr Infect Dis J 7: 863–866
Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Christiaan Hagen E, Hoffman GS, Hunder GG, Cees GM et al (1994) Nomenclature of systemic vasculatides proposal of an international consensus conference. Arthritis Rheum 37: 187–192
Fugimara H, Hamashima Y (1978) Pathology of the heart in Kawasaki disease. Pediatrics 61: 100–107
Leung DYM (1990) Immunologic aspects of Kawasaki syndrome. J Rheum 17(Suppl 24): 15–18
Leung DYM, Siegel RL, Grady S, Krensky A, Meade R, Reinherz EL, Geha R (1982) Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol 23: 100–112
Furukawa S, Matsubara T, Motohashi T, Nakachi S, Sasai K, Yabuta K (1990) Expressions of Fc epsilon R2/CD23 on peripheral blood macrophages/monocytes in Kawasaki disease. Clin Immunol Immunopathol 56: 280–286
Furukawa S, Matsubara T, Jujoh K, Yove K, Sagawara T, Sasai K, Kato H, Yabuto K (1988) Peripheral blood monocyte/macrophages and serum tumor necrosis factor in Kawasaki disease. Clin Immunol Immunopathol 48: 247–251
Lang BA, Silverman ED, Laxer RM, Lau AS (1989) Spontaneous tumor necrosis factor production in Kawasaki disease. J Pediatr 115: 939–943
Maurg CPJ, Salo E, Pelkonen P (1988) Circulating interleukin-1 in patients with Kawasaki disease. N Engl J Med 319: 1670–1671
Rowley AH Shulman ST, Preble OT, Poiesz BJ, Erlich GD, Sullivan JR (1988) Serum interferon concentrations and retroviral serology in Kawasaki syndrome. Pediatr Infect Dis J 7: 663–667
Ueno Y, Tokano N, Kanegane H, Yokoi T, Yachie A, Miyawaki T, Tauiguchi N (1989) The acute phase nature of interleukin-6: studies in Kawasaki disease and other febrile illnesses. Clin Exp Immunol 76: 337–342
Leung DYM, Collins T, Lapierre LA, Geha R, Pober J (1986) Immunoglobulin M antibodies present in the acute phase of Kawasaki serum lyse cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest 77: 1428–1435
Brown TJ, Crawford SE, Cornwall ML, Garcia F, Shulman ST, Rowley AH (2001) CD8 T-lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease. J Infect Dis 184: 940–943
Leung DYM, Burns JC, Newburger JW, Geba RS (1987) Reversal of lymphocyte activation in vivo in the Kawasaki syndrome by intravenous gamma globulin. J Clin Invest 79: 468–472
Avcin T, Tse SML, Schneider R, Ngan B, Silverman ED (2006) Macrophage activating syndrome as the presenting manifestation of rheumatic diseases in childhood. J Pediatr 148: 683–686
Furuno K, Yage T, Kusuhara K, Takada H, Nishio H, Khajoce V, Ohno T, Hara T (2004) CD25+ regulatory T-cells in patients with Kawasaki disease. J Pediatr 145: 385–390
Wang CL, Wu YT, Liu CA, Liu MW, Lee CJ, Huang LT, Yang KD (2003) Expression of CD40 ligand on CD4 T-cells and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease. Pediatrics 111: e140–147
Thornton S (2006) Contribution of angiogenic genes to the complex genetic train underlying Kawasaki disease. Arthritis Rheum 54: 1361–1365
Terai M, Yasukawa K, Marumoto S, Tateno S, Oaua S, Kohno Y (1999) Vascular endothelial growth factor in acute Kawasaki disease. Am J Cardiol 83: 337–339
Maeno N, Takei S, Masuda K, Akaike H, Matsuo K, Kitajima I, Maruyama I, Miyata K (1998) Increased serum levels of vascular endothelial growth factor in Kawasaki disease. Pediatr Res 44: 596–599
Ohno T, Igaroshi H, Inoue K, Akazawa K, Joho K, Hara T (2000) Serum vascular growth factor: a new predictive indicator for occurrence of coronary artery lesions in Kawasaki disease. Eur J Pediatr 159: 424–429
Gavin PJ, Crawford SE, Shulman ST, Garcia FL, Rowley AH (2003) Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. Arterioscler Thromb Vasc Biol 23: 576–581
Freeman AF, Crawford SE, Cornwall ML, Garcia FL, Shulman ST, Rowley AH (2005) Augiogenesis in fatal Kawasaki disease coronary artery and myocardium. Pediatr Cardiol 26: 578–584
Matsuda I, Hattori S, Magata N, Fruse A, Mambu H, Itakura K, Wakisaka A (1977) HLA antigens in mucocutaneous lymph node syndrome. Am J Dis Child 131: 1417–1418
Kato S, Kimura M, Tsuji K, Kusakawa S, Asar T, Juji T, Kawasaki T (1978) HLA antigens in Kawasaki disease. Pediatrics 61: 252–255
Krensky AM, Berenberg W, Shanley K, Yanis EJ (1981) HLA antigens in mucocutaneous lymph node syndrome in New England. Pediatrics 67: 741–743
Keren G, Davon YL, Orgal S, Kolt R, Gazit E (1982) HLA Bw 51 is increased in mucocutaneous lymph node syndrome. Tissue Antigens 20: 144–146
Krensky AM, Grady S, Shanley KM, Berenberg W, Yanis EJ (1983) Epidemic and endemic HLA-B and DR association in mucocutaneous lymph node syndrome. Hum Immunol 6: 75–77
Kamizono S, Yamada A, Higuchi T, Kato H, Itoh K (1999) Analysis of tumor necrosis factor-α production and polymorphisms of the tumor necrosis factor-α gene in individuals with a history of Kawasaki disease. Pediatr Int 41: 341–345
Jibiki T, Terai M, Shima M, Ogawa A, Hawada H, Kanegawa M, Yamamoto S, Kohno Y (2001) Monocyte chemoattractant 1 gene regulatory region polymorphism and serum level of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease. Arthritis Rheum 44: 2211–2212
Quasney MW, Bronstein DE, Cantor RM, Zhang Q, Stroupe C, Shike H, Bastian JF, Matsubara T, Fugimara M, Akimoto K et al (2001) Increased frequency of alleles associated with tumor necrosis factor-α levels in children with Kawasaki disease. Pediatr Res 49: 686–690
Ouchi K, Suzuki Y, Shirakawa T, Kishi F (2003) Polymorphism of SLC 11A1 (Formerly NRAMP1) gene confers susceptibility to Kawasaki disease. J Infect Dis 187: 326–329
Wu SF, Chang JS, Wan L, Tsai CH, Tsai FJ (2005) Association of IL-1Ra gene polymorphism, but no association of IL-1β and IL-4 gene polymorphisms with Kawasaki disease. J Clin Lab Anal 19: 99–102
Shim YH, Kim HS, Sohn S, Hong YM (2006) Insertion/deletion polymorphism of angiotensin converting enzyme gene in Kawasaki disease. J Korean Med Sci 21: 208–211
Brennis WB, Biezeveld MH, Geissler J, Ottenkamp, Kupers IM, Lam J, Hutchinson A, Weld R, Chanock SJ, Juijpers TW (2006) Vascular endothelial growth factor gene haplotypes in Kawasaki disease. Arthritis Rheum 54: 1588–1594
Takeuchi K, Yamamoto K, Kataoka S, Takihara T, Tamaka A, Soto S, Nichiyama M (1997) High incidence of angiotensin 1 converting enzyme genotype II in Kawasaki disease patients with coronary aneurysm. Eur J Pediatr 156: 266–268
Huang FY, Lee YJ, Chen MR, Hsu CH, Lin SP, Sung TC, Chang SC, Chang JG (2000) Polymorphism of transmembrane region of MICA gene and Kawasaki disease. Exp Clin Immunogen 17: 130–137
Tsukahara H, Hiraoka M, Saito M, Mishida K, Kobata, Tsuchida S, Tayooka M, Kimura H, Gejyo F, Myumi M (2000) Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease. Pediatr Int 42: 236–240
Mishimura S, Faitsu M, Megumi H, Yokata G, Watanabe M, Ueda Y, Imayoshi M, Ishii E, Tasaki H, Hamasaki Y (2003) A polymorphism in the promotor or the CD14 gene (CS14/-159) is associated with the development of coronary artery lesions in patients with Kawasaki disease. J Pediatr 143: 357–362
Onouchi Y, Onoue S, Tamari M, Makui K, Fukushima Y, Yashiro M, Nakamura Y, Yanagawa H, Kishi F, Ouchi K et al (2004) CD40 ligand gene and Kawasaki disease. J Hum Genet 12: 1062–1068
Kariazono H, Ohno T, Khajoee V, Ibara E, Kusuhara K, Kiirukawa N, Mizuna Y, Hora T (2004) Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease. Pediatr Res 56: 953–959
Park JA, Shin KS, Kim YW (2005) Polymorphism of matrix metalloprotemase-3 promotor gene as a risk factor for coronary artery lesions in Kawasaki disease. J Med Korean Ac 20: 607–660
Taniuchi S, Masuda M, Teraguchi M, Ikemoto Y, Kamiyama Y, Takahashi H, Kwo M, Koboyashi Y (2005) Polymorphism of Fcγ RIIa may affect the efficacy of gamma-globulin therapy in Kawasaki disease. J Clin Immunol 25: 309–313
Biezeveld MH, Geissler J, Wenerling GJ, Kuipers IM, Lam J, Ottenkamp J, Kuipers IM (2006) Polymorphisms in the mannose-bending lectin gene as determinants of age-defined risk or coronary artery lesions in Kawasaki disease. Arthritis Rheum 54: 369–376
Curtis N, Zheng R, Laub JR, Levin M (1995) Evidence for a superantigen mediated process in Kawasaki disease. Arch Dis Child 72: 308–311
Abe J, Kotgin BL, Jujo K, Melish ME, Glode MP, Kohsaka T, Leung DYM (1992) Selective expansion of T-cells expressing T-cell receptor variable regions Vβ2 and Vβ8 in Kawasaki disease. Proc Natl Acad Sci USA 89: 4066–4070
Leung DYM, Meissner HC, Fulton DR, Murray DL, Kotzin BL, Schlievert PM (1993) Toxic shock syndrome toxin secreting Staphylococcus aureus is Kawasaki syndrome. Lancet 342: 1385–1388
Yamashiro Y, Nagata S, Oguchi S, Shimizu T (1996) Selective increase Vβ2+ T-cells in the small intestinal mucosa in Kawasaki disease. Pediatr Res 39: 364–266
Leung DYM, Sullivan KE, Brown-Whitearm TF, Febringer AP, Allen S, Finkel TH, Washington RL, Makida R, Schlievert PM (1997) Association of toxic shock syndrome toxin-secreting Staphylococcus aureus with Kawasaki syndrome complicated by coronary artery disease. Pediatr Res 42: 268–272
Leung DYM, Meissner HC, Shulman ST, Mason WH, Gerber MA, Glode MP, Myones BL, Wheeler JG, Ruthazer R, Schlievert PM (2002) Prevalence of superantigen-secreting bacterial patients with Kawasaki disease. J Pediatr 140: 742–746
Nishiyori A, Sakaguchi M, Koto H (1994) Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome. Lancet 343: 299–300
Todome Y, Ohkuni H, Mizuse M, Okibayashi F, Olitave N, Suzuki H, Long C, Igarashi H, Harada K, Sakaurai S et al (1995) Superantigenic exotoxin production by isolates of Staphylococcus aureus from the Kawasaki syndrome patients and age-matched control children. J Med Microbial 42: 91–95
Pietra BA, Inocencio JD, Geannini EH, Hirsch R (1994) TCR Vβ family reparative and T-cell activation markers in Kawasaki disease. J Immunol 153: 1881–1888
Sakaguchi M, Kato H, Nishigori A, Sagawa K, Itoh K (1995) T-helper cells in patients with Kawasaki disease: preferential production of tumor necrosis factor-alpha (TNF alpha) by Yβ2-or Vβ8-CD4+ T-helper cells. Clin Exp Immunol 99: 276–282
Normura Y, Yoshinaga M, Masuda K, Takei S, Miyata K (2002) Maternal antibody against toxic syndrome toxin-1 may protect infants younger than 6 months of age from developing Kawasaki syndrome. J Infect Dis 185: 1677–1680
Nomura Y, Masuda K, Yoshinaga M, Takei S, Miyota K (2003) Possible relationship between streptococcal pyrogenic exotoxin A and Kawasaki syndrome in patients older than 6 months of age. Pediatr Infect Dis J 22: 794–798
Matsubara K, Fukaya T, Miwa K, Shibayama N, Nigami H, Hirata T, Baba K, Suzuki T, Ishiguro A (2006) Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease. Clin Exp Immunol 143: 427–434
Curtis N (2004) Kawasaki disease and toxic shock syndrome — at last the etiology is clear? Adv Exp Med Biol 549: 191–200
Rowley AH, Eckerly CA, Jack HM, Shulman ST, Baker SC (1997) IgA PC in vascular tissue of patients with Kawasaki disease. J Immunol 159: 5946–5995
Rowley AH, Shulman ST, Mask CA, Finn LS, Terai M, Baker SC, Galliani CA, Takahashi K, Mooe S, Kalelkar MB, Crawford SE (2000) IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney and coronary artery in acute Kawasaki syndrome. J Infect Dis 182: 1183–1191
Faden H, Modlin JF, McBean AM, Ferden MB, Ogra PL (1990) Comparative evaluation of immunization with live attenuated and enhanced-potency inactivated trivalent poliovirus vaccines in childhood: systemic and local immune responses. J Infect Dis 162: 1291–1297
Rowley AH, Baker SC, Garcia FL, Guzman-Cottrill JA, Chou P, Terai M, Kawasaki T, Kalelkar MB, Crawford SE (2004) Detection of antigen in bronchial epithelium and macrophages in acute Kawasaki disease by use of synthetic antibody. J Infect Dis 190: 856–865
Rowley AH, Shulman ST, Spike BT, Mask CA, Baker SC (2001) Oligoclonal IgA response in the vascular wall in acute Kawasaki disease. J Immunol 166: 1334–1343
Rowley AH, Baker S, Shulman ST, Fox LM, Takahashi K, Garcia FL, Crawford SE, Chou P, Orenstein JM (2005) Cytoplasmic inclusion bodies are detected by synthetic antibody in ciliated bronchial epithelium during acute Kawasaki disease. J Infect Dis 192: 1757–1766
van der Hoek L, Pyrc K, Jibbink, MF, Vermuelin-Oost W, Berkhout KC, Wertheim-van Dillen PM, Kaandorp J, Berkhout B (2004) Identification of a new human coronavirus. Nat Med 10: 368–373
Esper F, Weibel C, Ferguson D, Landry ML, Kahn JS (2005) Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children. J Infect Dis 191: 492–498
Esper F, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS (2005) Association between a novel human coronavirus and Kawasaki disease. J Infect Dis 191: 499–502
Ebihara T, Endo R, Ma X, Ishiguro N, Kikuta H (2005) Lack of association between New Haven coronavirus and Kawasaki disease. J Infect Dis 192: 351–352
Belay ED, Erdman DD, Anderson LJ, Peret TCT, Schrag SJ, Fields BS, Burus JC, Schonberger LB (2005) Kawasaki disease and human coronavirus. J Infect Dis 192: 352–353
Shimizu C, Shuke H, Baker SC, Garcia F, van der Hoek L, Kuijpers TW, Reed SL, Rowley AH, Shulman ST, Talbot HKB et al (2005) Human coronavirus NL63 is not detected in the respiratory tract of children with acute Kawasaki disease. J Infect Dis 192: 1767–1771
Chang LY, Chiang BL, Lao CL, We MH, Chen PJ, Berkhout B, Yang HC, Huang LM (2006) Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan. J Infect Dis 193: 283–286
Kahn JS (2006) The widening scope of coronaviruses. Curr Opin Pediatr 18: 42–47
Weissbrich BM, Weske F, Schubert J, Tollmann F, Blath K, Blessing K, Kreth HW (2006) Frequent detection of bocavirus DNA in German children with respiratory tract infections. BMC Infect Dis 6: 109
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Mason, W. (2007). Epidemiology and etiology of Kawasaki disease. In: Schroten, H., Wirth, S. (eds) Pediatric Infectious Diseases Revisited. Birkhäuser Advances in Infectious Diseases. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8099-1_10
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