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Role of α6β1 integrin in leukocyte adhesion and transmigration

  • Mathieu-Benoit Voisin
  • Sussan Nourshargh
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Integrins are a family of heterodimeric cell-surface adhesion and signaling molecules each composed of an α and a β subunit. At present 18 α and 8 β subunits have been identified giving rise to 24 distinct integrin molecules. Many members of this family, primarily integrins containing a β1 subunit, act as receptors for extracellular matrix proteins, e.g., α1β1 and α2β1 are key receptors for collagen while α3β1 and α6β1 are key receptors for laminin. The integrin α6β1 (VLA-6, CD49f/CD29) was originally identified on platelets but is now known to be expressed on numerous cell types including epithelial and endothelial cells and is indeed the key leukocyte laminin receptor. Its principal functional role relates to regulation of cell adhesion and motility, and, in line with this, α6β1 interaction with its ligands leads to cellular cytoskeletal rearrangement and polarization. In the context of inflammatory events, the ability of α6β1 to bind vascular laminins has led to much interest in the role of this integrin in regulation of leukocyte migration through the vascular basement membrane (BM). In blood vessels, the BM forms a thin protein sheet that underlies the endothelium and encases the pericytes/smooth muscle cells. Major constituents of this BM are laminins (laminin 8 and laminin 10) and collagen IV, which form two independent networks that are interconnected by molecules such as nidogens (nidogen-1 and nidogen-2) and the large heparan sulfate proteoglycan, perlecan [1]. In contrast to our growing knowledge of the molecules and mechanisms that mediate leukocyte migration through the endothelium [2], less is known about the mechanisms that mediate and regulate leukocyte migration through the vascular BM.

Keywords

Leukocyte Adhesion Bullous Pemphigoid Neutrophil Migration Leukocyte Migration Integrin Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Mathieu-Benoit Voisin
    • 1
  • Sussan Nourshargh
    • 1
  1. 1.Centre for Microvascular Research, Williams Harvey Research InstituteQueen Mary and Westfield CollegeLondonUK

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