PECAM: Regulating the start of diapedesis

  • William A. Muller
Part of the Progress in Inflammation Research book series (PIR)


The molecules involved in the capturing, rolling, adhesion, and locomotion steps of leukocyte emigration have been described in earlier chapters in this book. PECAM is primarily involved in diapedesis — the step in which leukocytes squeeze in ameboid fashion between the tightly apposed endothelial cells that line the blood vessels at a site of inflammation. It is also the “point of no return” for the leukocyte. In vivo as viewed by intravital microscopy, the preceding steps of capturing, rolling, locomotion, and adhesion are reversible. Most leukocytes that enter a postcapillary venule at the site of inflammation are not captured; many of the leukocytes that do adhere to the endothelium release back into the circulation. Once the leukocyte commits to diapedesis, however, it continues to migrate into the inflamed tissue and does not return to the circulation — at least not as the same cell.


Transendothelial Migration Intratracheal Instillation Postcapillary Venule Platelet Endothelial Cell Adhesion Homophilic Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • William A. Muller
    • 1
  1. 1.Department of Pathology and Laboratory Medicine and the Graduate Program in Immunology and Microbial PathogenesisWeill Medical College of Cornell UniversityNew YorkUSA

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