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Lymphocyte function-associated antigen-1 (LFA-1) and macrophage antigen-1 (Mac-1): Cooperative partners in leukocyte emigration and function

  • Alan R. Schenkel
  • Minsoo Kim
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Lymphocyte function-associated antigen-1 (LFA-1; [1]) and macrophage antigen-1 (Mac-1; [2]) are some of the best-characterized integrins. Like other integrins, their diverse relationships and functions have lead to complex nomenclature. Integrins are heterodimeric receptors, consisting of type-I transmembrane glycoprotein α and β subunits. The a subunits of LFA-1 and Mac-1 were first named as αL and αM, respectively, in 1983 [3, 4, 5] . The Third International Workshop on Human Leukocyte Differentiation Antigens assigned αL subunit as CD11a and αM subunit as CD11b, and the common β2 subunit as CD18 [6] The common β2 subunit of LFA-1 (αLβ2) and Mac-1 (αMβ2), forms a family with αxβ2 (p150,95, CD11c/CD18), and αDβ2 (CD11d/CD18). All four are expressed predominately on leukocytes [1, 7]. Another name of Mac-1 is complement receptor type-3 (CR3; [8]). Mac-1 had been called Mo-1 and OKM-1 early on until the antibodies were shown to recognize the same proteins [3, 6, 7, 9].

Keywords

Transendothelial Migration Immunological Synapse Leukocyte Adhesion Deficiency Supramolecular Activation Cluster Talin Head Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Alan R. Schenkel
    • 1
  • Minsoo Kim
    • 2
  1. 1.Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort CollinsUSA
  2. 2.Department of Surgery, Division of Surgical ResearchRhode Island Hospital and Brown University School of MedicineProvidenceUSA

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