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α4-integrins: structure, function and secrets

  • Britta Engelhardt
Part of the Progress in Inflammation Research book series (PIR)

Abstract

The initial description of α4β1integrin dates back 30 years, when in 1987, based on biochemical studies, Martin Hemler and co-workers [1] described it as a distinct Mr 150 000/130 000 α4β heterodimer and thus a new member of the VLA-protein family on human T lymphoblastoid cells and peripheral blood T cells. Interestingly, some of the most widely used and characterized antibodies against α4-integrin were originally described by Sanchez-Madrid in 1986 against VLA-3 in error [2]. The name VLA (very late activation) antigen was originally coined to describe a novel set of antigens that appeared in a very late stage of activated T cell differentiation [3]. VLA antigens were found to be composed of non-covalently associated heterodimers with a common β-subunit but unique α-subunits, and were readily recognized as members of the larger integrin family of adhesion receptors. These receptors are involved in a multitude of distinct cell-matrix and cell-cell adhesion functions. Based on their discovery, β1-integrins are often referred to as VLA antigens, therefore α4β1-integrin is still mostly referred to as VLA-4 until today. The corresponding term of the CD nomenclature for α4β1-integrin is CD49dCD29.

Keywords

Experimental Autoimmune Encephalomyelitis Progressive Multifocal Leukoencephalopathy Progressive Multifocal Leukoencephalopathy Integrin Alpha Propeller Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Britta Engelhardt
    • 1
  1. 1.Theodor Kocher InstituteUniversity of BernBernSwitzerland

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