Endothelial ICAM-1 functions in adhesion and signaling during leukocyte recruitment

  • Scott D. Auerbach
  • Lin Yang
  • Francis W. Luscinskas
Part of the Progress in Inflammation Research book series (PIR)


Intercellular adhesion molecule-1 (ICAM-1, CD54) was identified more than 20 years ago as a cytokine-inducible adhesion molecule [1]. Endothelial cell ICAM-1 surface expression is elevated at sites of endothelial cell activation in vivo and in vitro, and contributes to stable adhesion and transmigration of circulating blood leukocytes through its interaction with leukocyte β2 integrins. This chapter briefly reviews ICAM-1 structure and function, and then address the mechanisms through which ICAM-1-dependent adhesion and signaling control leukocyte transmigration.


Brain Endothelial Cell Fluorescence Recovery After Photobleaching Leukocyte Recruitment Cytoskeletal Remodel Leukocyte Transmigration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Scott D. Auerbach
    • 1
  • Lin Yang
    • 1
  • Francis W. Luscinskas
    • 1
  1. 1.Center for Excellence in Vascular Biology, Departments of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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