Structure and function of JAM proteins

  • Eric A. Severson
  • Charles A. Parkos
Part of the Progress in Inflammation Research book series (PIR)


The immunoglobulin superfamily (IgSF) is a large class of proteins that includes the junctional adhesion molecule (JAM) family of proteins. The current nomenclature for JAM members designates the first three described JAM proteins as JAM-A, JAM-B, JAM-C. Two other related proteins have been reported that have not been included in the standard nomenclature and are termed JAM-4 and JAM-L (AMICA). In earlier studies, numerical designations were used to define JAM proteins according to the timing of initial characterizations. However, this early nomenclature led to confusion in terminology for JAM-B and C due to the timing in which human and murine JAM-B and JAM-C were reported. To avoid confusion, this review uses current nomenclature exclusively, as proposed originally by Müller, regardless of the designation given in the original reports [1].


Tight Junction Junctional Adhesion Junctional Adhesion Molecule Leukocyte Transmigration Leukocyte Integrin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag Basel/Switzerland 2007

Authors and Affiliations

  • Eric A. Severson
    • 1
  • Charles A. Parkos
    • 1
  1. 1.Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory MedicineEmory University School of MedicineAtlantaUSA

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